EVIDENCE FOR DOPAMINE-RECEPTOR PRUNING BETWEEN ADOLESCENCE AND ADULTHOOD IN STRIATUM BUT NOT NUCLEUS-ACCUMBENS
EVIDENCE FOR DOPAMINE-RECEPTOR PRUNING BETWEEN ADOLESCENCE AND ADULTHOOD IN STRIATUM BUT NOT NUCLEUS-ACCUMBENS
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DOI：
10.1016/0165-3806(95)00109-q
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发表时间：
1995-11-21
期刊：
影响因子：
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通讯作者：
HOSTETTER, JC
中科院分区：
文献类型：
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作者：
TEICHER, MH;ANDERSEN, SL;HOSTETTER, JC
采用放射自显影技术研究大鼠出生后25、35、40、60、80、100和120天纹状体和伏隔核多巴胺D-1和D-2受体家族的发育情况。选择这些年龄是为了验证多巴胺受体在青春期（第40天）之前过量产生，然后被修剪回成人水平的假设。这一假设在纹状体中得到证实，但在伏隔核中没有。D-1受体B-max （[H-3]SCH-23390）在40天达到峰值，水平比25天高67 +/- 21%。然而，B-max水平在60-120天时比40天时至少降低35%。同样，D-2受体数量（[H-3]YM-09151-2）在25 ~ 40天增加了144 +/- 26%，而在60 ~ 120天减少了34 ~ 38%。相反，D-1和D-2受体B-max在25 ~ 40天时增加约150%，在60、80天时略有下降，但在100、120天时与40天时无显著差异。这些发现表明，这两个主要的多巴胺靶区遵循不同的发育策略，这对关注受体异常修剪的精神分裂症病因学理论具有启示意义。
Postnatal development of dopamine D-1 and D-2 receptor families in striatum and nucleus accumbens of rats was studied at 25, 35, 40, 60, 80, 100 and 120 days using autoradiography. These ages were selected to test the hypothesis that dopamine receptors were overproduced prior to puberty (day 40), and pruned back to adult levels thereafter. This hypothesis was confirmed in striatum but not nucleus accumbens. D-1 receptor B-max ([H-3]SCH-23390) peaked at 40 days, with levels 67 +/- 21% greater than at 25 days. However, B-max levels were at least 35% lower at 60-120 days than at 40 days. Similarly, D-2 receptor numbers ([H-3]YM-09151-2) increased 144 +/- 26% between 25 and 40 days, but were reduced by 34-38% between 60-120 days. In contrast, D-1 and D-2 receptor B-max increase approximately 150% between 25 and 40 days in nucleus accumbens, levels fell slightly at 60 or 80 days, but were no different at 100 and 120 days then they were at 40 days. These findings suggest that these two major dopamine target regions follow different developmental strategies, and this has implications for etiological theories of schizophrenia that focus on anomalous receptor pruning.