Sleep-inducing effect of substance P-cholera toxin A subunit in mice.
Sleep-inducing effect of substance P-cholera toxin A subunit in mice.
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DOI：
10.1016/j.neulet.2017.08.066
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发表时间：
2017-10-17
影响因子：
2.5
通讯作者：
Gerashchenko D
中科院分区：
文献类型：
--
作者：
Zielinski MR;Gerashchenko D
Evidence indicates that the neuropeptide substance P (SP) can act through neurokinin receptors to alter sleep and/or non-rapid eye movement (NREM) sleep slow-wave activity. Consequently, drugs acting on SP receptors could potentially be used as a novel treatment for sleep-related disorders. In the present study, we used SP conjugated with cholera toxin A subunit (SP-CTA), which enhances its duration of activity on SP receptors, to determine the effects of selectively activating SP-expressing brain cells on sleep regulation in mice. Herein, we found that intracerebroventricular administration of SP-CTA enhanced amounts of NREM sleep which was highly fragmented. This result suggests that the activation of SP receptor-expressing cells in the brain can produce not only arousal effects as shown in previous studies but also sleep-inducing effects.
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DOI：
10.1523/jneurosci.1809-08.2008
发表时间：
2008-10-01
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Cano G;Mochizuki T;Saper CB
通讯作者：
Saper CB
影响因子：
5.5
作者：
Jafri, MS;Weinreich, D
通讯作者：
Weinreich, D
影响因子：
3.3
作者：
McConalogue, K;Corvera, CU;Bunnett, NW
通讯作者：
Bunnett, NW
影响因子：
5.6
作者：
Ratti, Emiliangelo;Carpenter, David J.;Merlo-Pich, Emilio
通讯作者：
Merlo-Pich, Emilio
影响因子：
3.3
作者：
Saffroy, M;Torrens, Y;Beaujouan, JC
通讯作者：
Beaujouan, JC