Gentle cleansing and moisturizing for patients with atopic dermatitis and sensitive skin.
Gentle cleansing and moisturizing for patients with atopic dermatitis and sensitive skin.
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DOI：
10.2165/0128071-200910001-00003
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发表时间：
2009-01-01
影响因子：
7.3
通讯作者：
Cheong, Wai Kwong
中科院分区：
文献类型：
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作者：
Cheong, Wai Kwong
特应性皮炎是一种以皮肤瘙痒、炎症和干燥为特征的常见病症。炎症破坏角质层的屏障功能，使皮肤易于干燥，并增加对刺激物和继发性细菌感染的易感性。敏感性皮肤是常见的，在美国，欧洲和日本有40-50%的女性和30%的男性报告。管理湿疹和敏感皮肤的基本要求包括有效的清洁剂，这些清洁剂不会损害皮肤屏障的完整性，减轻皮肤干燥，并通过使用治疗性保湿剂恢复皮肤屏障功能。因此，选择皮肤清洁剂是管理这些条件的重要组成部分。研究报告了使用无皂清洁剂结合局部治疗的临床改善。虽然局部皮质类固醇和免疫抑制剂是治疗特应性皮炎的主要药物，但治疗性保湿剂也是重要的补充剂。保湿剂改善皮肤水合作用，降低对刺激的敏感性，恢复角质层的完整性，并增强局部皮质类固醇的功效。
Atopic dermatitis is a common condition characterized by pruritus, inflammation, and dryness of the skin. Inflammation disrupts the barrier function of the stratum corneum, predisposing the skin to be dry, and increases susceptibility to irritants and secondary bacterial infection. Sensitive skin is common, reported by 40-50% of women and 30% of men in the US, Europe, and Japan. Basic requirements in managing eczema and sensitive skin include effective cleansers that do not compromise skin barrier integrity, alleviation of skin dryness, and restoration of skin barrier function through the use of therapeutic moisturizers. The selection of a skin cleanser is therefore an important part of managing these conditions. Studies have reported clinical improvement with the use of soap-free cleansers in combination with topical treatments. While topical corticosteroids and immunosuppressive agents are mainstays of treatment for atopic dermatitis, therapeutic moisturizers are important adjuncts. Moisturizers improve skin hydration, reduce susceptibility to irritation, restore the integrity of the stratum corneum, and enhance the efficacy of topical corticosteroids.