Current ante-mortem techniques for diagnosis of bovine tuberculosis
Current ante-mortem techniques for diagnosis of bovine tuberculosis
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DOI：
10.1016/j.rvsc.2014.04.002
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发表时间：
2014-10-01
影响因子：
2.4
通讯作者：
Dominguez, Lucas
中科院分区：
文献类型：
--
作者：
Bezos, Javier;Casal, Carmen;Dominguez, Lucas
牛结核病（TB）主要由牛分枝杆菌（Mycobacterium bovis）引起，是一种人畜共患疾病，对公共卫生有影响，并由于产量下降和贸易限制而产生经济影响。牛结核病的官方根除运动主要基于检测和屠宰政策，使用基于细胞介导免疫反应的诊断测定法，如皮内结核菌素试验和γ-干扰素（IFN-γ）测定法。此外，在过去的几年中，已经开发了几种基于特异性抗体（Ab）检测的诊断测定，目的是在不久的将来补充当前的诊断技术。本文综述了目前用于牛结核病诊断的宰前诊断工具的历史背景、方法学以及在不同流行病学情况下先前研究中获得的灵敏度（Se）和特异性（Sp）。(C)2014爱思唯尔有限公司版权所有。
Bovine tuberculosis (TB), mainly caused by Mycobacterium bovis, is a zoonotic disease with implications for Public Health and having an economic impact due to decreased production and limitations to the trade. Bovine TB is subjected to official eradication campaigns mainly based on a test and slaughter policy using diagnostic assays based on the cell-mediated immune response as the intradermal tuberculin test and the gamma-interferon (IFN-gamma) assay. Moreover, several diagnostic assays based on the detection of specific antibodies (Abs) have been developed in the last few years with the aim of complementing the current diagnostic techniques in the near future. This review provides an overview of the current ante-mortem diagnostic tools for diagnosis of bovine TB regarding historical background, methodologies and sensitivity (Se) and specificity (Sp) obtained in previous studies under different epidemiological situations. (C) 2014 Elsevier Ltd. All rights reserved.