Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestine.
Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestine.
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Lipocalin-2 抗性赋予肠沙门氏菌血清型鼠伤寒在发炎肠道中生长和存活的优势。
DOI：
10.1016/j.chom.2009.03.011
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发表时间：
2009-05-08
影响因子：
30.3
通讯作者：
Bäumler AJ
中科院分区：
文献类型：
--
作者：
Raffatellu M;George MD;Akiyama Y;Hornsby MJ;Nuccio SP;Paixao TA;Butler BP;Chu H;Santos RL;Berger T;Mak TW;Tsolis RM;Bevins CL;Solnick JV;Dandekar S;Bäumler AJ
肠道沙门氏菌血清型鼠伤寒沙门氏菌在急性发炎的肠腔中生长旺盛，这表明该病原体对在该环境中遇到的抗菌剂具有耐药性。然而，这些抗菌剂和相应的细菌耐药基因的身份仍然难以捉摸。在这里，我们表明，肠道感染的S。鼠伤寒引起肠上皮细胞中脂质运载蛋白-2（一种防止细菌铁获得的抗菌蛋白）的显著白细胞介素（IL）-22/IL-17介导的诱导。Lipocalin-2在恒河猴S.鼠伤寒感染。由iroBCDE iroN基因座介导的对脂质运载蛋白-2的抗性赋予了S.野生型鼠伤寒沙门氏菌在野生型小鼠的发炎肠道中定植，但在脂质运载蛋白-2缺陷小鼠中不定植。这些数据支持对脂质运载蛋白-2的抗性定义了对发炎肠道中生长的特定适应。
Salmonella enterica serotype Typhimurium thrives in the lumen of the acutely inflamed intestine, which suggests that this pathogen is resistant to antimicrobials encountered in this environment. However, the identity of these antimicrobials and the corresponding bacterial resistance genes remains elusive. Here we show that enteric infection with S. Typhimurium evoked marked interleukin (IL)–22/IL-17 mediated induction in intestinal epithelial cells of lipocalin-2, an antimicrobial protein that prevents bacterial iron acquisition. Lipocalin-2 accumulated in the intestinal lumen of rhesus macaques during S. Typhimurium infection. Resistance to lipocalin-2, mediated by the iroBCDE iroN locus, conferred a competitive advantage upon the S. Typhimurium wild-type in colonizing the inflamed intestine of wild-type, but not of lipocalin-2 deficient mice. These data support that resistance to lipocalin-2 defines a specific adaptation to growth in the inflamed intestine.
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DOI：
10.1073/pnas.0737682100
发表时间：
2003-04-01
影响因子：
11.1
作者：
Hantke, K;Nicholson, G;Winkelmann, G
通讯作者：
Winkelmann, G
影响因子：
6.4
作者：
Bauer, RJ;Zhang, LX;Marrs, CF
通讯作者：
Marrs, CF
影响因子：
3.6
作者：
Crouch, Marie-Laure V.;Castor, Margaret;Fang, Ferric C.
通讯作者：
Fang, Ferric C.
DOI：
10.1073/pnas.0510847103
发表时间：
2006-02-07
影响因子：
11.1
作者：
Berger, T;Togawa, A;Mak, TW
通讯作者：
Mak, TW
影响因子：
16
作者：
Goetz, DH;Holmes, MA;Strong, RK
通讯作者：
Strong, RK