Antibacterial activity, osteogenic and angiogenic behaviors of copper-bearing titanium synthesized by PIII&D
Antibacterial activity, osteogenic and angiogenic behaviors of copper-bearing titanium synthesized by PIII&D
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PIII合成的含铜钛的抗菌活性、成骨和血管生成行为
DOI：
10.1039/c5tb02300a
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发表时间：
2016
影响因子：
7
通讯作者：
Liu Xuanyong
中科院分区：
文献类型：
--
作者：
Yu Le;Jin Guodong;Ouyang Liping;Wang Donghui;Qiao Yuqin;Liu Xuanyong
含铜生物材料在硬组织替代方面引起了人们的极大兴趣。然而，仍然需要在结合的铜的生物相容性和细胞毒性之间进行更好的折衷。在这项工作中，两种类型的铜轴承表面上获得钛通过改变工艺参数在PIII&D。在Ti表面上具有一定量的金属形式的铜的一种显示出增强的抗菌能力、成骨和血管生成能力，而在含Cu纳米颗粒的存在下从另一种Ti表面观察到不利的生物相容性。通过相同的单一技术合成的两种类型的含铜钛表面之间的不同生物学差异为更好地理解含铜生物材料的积极和消极生物效应之间的潜在机制提供了见解。
Cu-bearing biomaterials have drawn considerable interest in hard tissue replacement. However, a better compromise between the biocompatibility and cytotoxicity of incorporated copper is still required. In this work, two types of Cu-bearing surfaces were obtained on Ti by altering the processing parameters during PIII&D. One with a certain amount of copper in metallic form on the Ti surface shows enhanced antibacterial ability, osteogenic and angiogenic capabilities, whereas unfavorable biocompatibility is observed from the other Ti surface in the presence of Cu-bearing nanoparticles. Disparate biological differences between two types of Cu-bearing Ti surfaces synthesized by the same single technique provides insights for better understanding of the underlying mechanism between the positive and negative bioeffects of Cu-bearing biomaterials.