Study design and cohort characteristics of the childhood cancer survivor study: A multi-institutional collaborative project
Study design and cohort characteristics of the childhood cancer survivor study: A multi-institutional collaborative project
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DOI：
10.1002/mpo.1316
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发表时间：
2002-04-01
期刊：
影响因子：
--
通讯作者：
Zeltzer, LK
中科院分区：
文献类型：
--
作者：
Robison, LL;Mertens, AC;Zeltzer, LK
背景。人们越来越关注儿童癌症幸存者的长期健康状况。为了促进此类研究，一个多机构联盟建立了儿童癌症幸存者研究（Childhood Cancer Survivor Study，CCSS），这是一个大型、多样化、特征明确的儿童和青少年癌症 5 年幸存者队列。研究过程。CCSS队列的资格包括1970-1986年期间21岁之前确诊癌症并存活至少5年的特定人群。结果。从 25 个参与机构中共确定了 20276 名符合条件的受试者，其中 15%的受试者被认为失去了随访机会。目前，已有 14,054 名受试者（占合格人群的 69.3%）填写了 24 页的基线问卷。首次诊断结果的分布情况包括白血病（33%）、淋巴瘤（21%）、神经母细胞瘤（7%）、中枢神经系统肿瘤（13%）、骨肿瘤（8%）、肾肿瘤（9%）和软组织肉瘤（9%）。98%的研究参与者已成功完成化疗、放疗和手术的病历提取。总体而言，78%的人接受了放疗，73%的人接受了化疗。结论CCSS代表了北美地区规模最大、特征最广泛的儿童和青少年癌症幸存者群组。它是解决这一独特且不断增长的人群中二次恶性肿瘤风险、内分泌和生殖结果、心肺并发症和社会心理影响等重要问题的资源。Med Pediatr Oncol 2002;38:229-239.(C) 2002 Wiley-Liss, Inc.
Background. Increased attention has been directed toward the long-term health outcomes of survivors of childhood cancer. To facilitate such research, a multi-institutional consortium established the Childhood Cancer Survivor Study (CCSS), a large, diverse, and well-characterized cohort of 5-year survivors of childhood and adolescent cancer. Procedure. Eligibility for the CCSS cohort included a selected group of cancer diagnoses prior to age 21 years between 1970-1986 and survival for at least 5 years. Results. A total of 20,276 eligible subjects were identified from the 25 contributing institutions, of whom 15% are considered lost to follow-up. Currently, 14,054 subjects (69.3% of the eligible cohort) have participated by completing a 24-page baseline questionnaire. The distribution of first diagnoses includes leukemia (33%), lymphoma (21%), neuroblastoma (7%), CNS tumor (13%), bone tumor (8%), kidney tumor (9%), and soft-tissue sarcoma (9%). Abstraction of medical records for chemotherapy, radiation therapy, and surgical procedures has been successfully completed for 98% of study participants. Overall, 78% received radiotherapy and 73% chemotherapy. Conclusion. The CCSS represents the largest and most extensively characterized cohort of childhood and adolescent cancer survivors in North America. It serves as a resource for addressing important issues such as risk of second malignancies, endocrine and reproductive outcome, cardiopulmonary complications, and psychosocial implications, among this unique and ever-growing population. Med Pediatr Oncol 2002;38:229-239. (C) 2002 Wiley-Liss, Inc.