COLD-PRESSER PAIN TOLERANCE IN OPIATE AND COCAINE ABUSERS - CORRELATES OF DRUG TYPE AND USE STATUS
COLD-PRESSER PAIN TOLERANCE IN OPIATE AND COCAINE ABUSERS - CORRELATES OF DRUG TYPE AND USE STATUS
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DOI：
10.1016/0885-3924(94)90203-8
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发表时间：
1994-10-01
影响因子：
4.7
通讯作者：
COMPTON, MA
中科院分区：
文献类型：
--
作者：
COMPTON, MA
本研究的目的是描述药物滥用者的疼痛耐受性。研究表明，药物依赖和疼痛感知具有共同的神经解剖学和神经生理学基础;因此，精神活性药物的滥用被假设与疼痛耐受性有关。我们检查了122名男性，当前和以前的阿片类药物和可卡因滥用者的冷加压疼痛耐受性，包括使用状态和主要滥用药物。描述性分析表明，疼痛敏感者与疼痛耐受者的比例远高于规范性冷加压疼痛文献中的描述。双向方差分析显示，使用状态的显着的主效应，表明目前的药物使用与疼痛耐受性下降。对药物类型的主要影响是将滥用视为相互关联的现象。
The objective of this study was to describe pain tolerance in drug abusers. Research suggests that drug dependence and pain perception share common neuroanatomical and neurophysiological substrates; thus the abuse of psychoactive drugs was hypothesized to relate to pain tolerance. We examined cold-pressor pain tolerance in 122 male, current and former opioid and cocaine abusers, across use status and primary drug of abuse. Descriptive analyses showed that the ratio of pain-sensitive to pain-tolerant persons was considerably higher than that described in the normative cold-pressor pain literature. Two-way analysis of variance revealed a significant main effect for using status, indicating that current drug use is associated with decreased pain tolerance. The main effect for drug type approached abuse as interrelated phenomena.