ANTAGONISM OF THE BEHAVIORAL-EFFECTS OF ETHANOL BY NALTREXONE IN BALB/C, C57BL/6, AND DBA/2 MICE
ANTAGONISM OF THE BEHAVIORAL-EFFECTS OF ETHANOL BY NALTREXONE IN BALB/C, C57BL/6, AND DBA/2 MICE
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DOI：
10.1007/bf00433403
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发表时间：
1983-01-01
影响因子：
3.4
通讯作者：
TABAKOFF, B
中科院分区：
文献类型：
--
作者：
KIIANMAA, K;HOFFMAN, PL;TABAKOFF, B
The effects of naltrexone on the increase in locomotor activity induced by a low dose (1.35 g/kg i.p.) of ethanol and on the duration of loss of righting reflex after a high dose (3.5 g/kg) of ethanol were studied in BALB c, DBA 2 and C57BL 6 mice. Ethanol increased locomotor activity in DBA and BALB mice, but not in C57BL mice. Naltrexone, at a dose of 0.1 mg/kg, antagonized the ethanol-induced increase in locomotion similarly in DBA and BALB mice. The duration of loss of righting reflex was differentially affected in all 3 strains by naltrexone. The BALB mice were the most sensitive strain (1 mg/kg naltrexone significantly counteracted ethanol hypnosis), the C57BL mice were intermediate (8 mg/kg naltrexone required to antagonize this effect of ethanol) and the DBA mice were least sensitive (no effect evident even at the highest dose of 8 mg/kg) to naltrexone. Naltrexone could antagonize the behavioral effects of a low and high dose of ethanol, but the 3 strains, which differ in their behavioral response to ethanol, were differentially sensitive to the effect of naltrexone in reversing ethanol-induced hypnosis and ethanol-induced changes in locomotor activity.
