Sesquiterpenes from the Leaves of Magnolia delavayi Franch. and Their Cytotoxic Activities
Sesquiterpenes from the Leaves of Magnolia delavayi Franch. and Their Cytotoxic Activities
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来自 Magnolia delavayi Franch 叶子的倍半萜。
DOI：
10.1002/cbdv.201900013
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发表时间：
2019-05-01
影响因子：
2.9
通讯作者：
Zhao, Qin-Shi
中科院分区：
文献类型：
--
作者：
Xie, Zhang-Qiao;Ding, Lin-Fen;Zhao, Qin-Shi
从白玉兰叶95%乙醇提取物中分离得到13个倍半萜，其中8个为新化合物，magnnodelavins A-H（1-8）。通过详尽的H-1-， C-13-, 2D-NMR， UV， IR和HR-ESI-MS数据以及x射线晶体学分析确定了新化合物的结构。化合物9和10在体外对HL-60、A-549、SMMC-7721、MCF-7和SW480人癌细胞具有较强的细胞毒活性。
Thirteen sesquiterpenes including eight new ones, magnodelavins A-H (1-8), were obtained from the 95% ethanolic extract of the leaves of Magnolia delavayiFranch. The structures of the new compounds were determined by exhaustive H-1-, C-13-, 2D-NMR, UV, IR, and HR-ESI-MS data, as well as X-ray crystallographic analysis. Compounds 9 and 10 showed potent cytotoxic activities against HL-60, A-549, SMMC-7721, MCF-7, and SW480 human cancer cell lines invitro using MTS assay.