Biodegradable Thermoresponsive Microparticle Dispersions for Injectable Cell Delivery Prepared Using a Single-Step Process
Biodegradable Thermoresponsive Microparticle Dispersions for Injectable Cell Delivery Prepared Using a Single-Step Process
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DOI：
10.1002/adma.200800382
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发表时间：
2009-05-11
影响因子：
29.4
通讯作者：
Alexander, Cameron
中科院分区：
文献类型：
--
作者：
Wang, Wenxin;Liang, He;Alexander, Cameron
表面工程微粒；具有可生物降解的聚合物核心和可编程的热响应性生物兼容共聚聚合物电晕。在37摄氏度以下，粒子形成自由流动的分散体，但在此温度以上，由于共聚物电晕的链状崩溃，粒子形成多孔的空间填充凝胶。当颗粒与生物材料混合时，它们会形成能够支持细胞生长的胶囊化。
Surface-engineered microparticles; with a biodegradable polymer core and a programmable thermoresponsive biocompatible copolymer corona are produced. The particles form free-flowing dispersions below 37 degrees C, but form porous space-filling gels above this temperature, as a result of chain collapse of the copolymer corona. When particles are mixed with biological materials, they form encapsulating gels that can support cell growth.