Nickel-Catalyzed Intermolecular [2+2] Cycloaddition of Conjugated Enynes with Alkenes
Nickel-Catalyzed Intermolecular [2+2] Cycloaddition of Conjugated Enynes with Alkenes
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DOI：
10.1021/ja3074775
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发表时间：
2012-09-26
影响因子：
15
通讯作者：
Ogoshi, Sensuke
中科院分区：
文献类型：
--
作者：
Nishimura, Akira;Ohashi, Masato;Ogoshi, Sensuke
研究了镍催化的共轭烯炔与烯烃的分子间[2 + 2]环加成反应。各种缺电子烯烃以及电子中性的正癸烯和1-癸烯都适用于该反应。共轭烯炔的使用避免了可能的副反应，如低聚和环三聚。反应中间体配合物的分离表明，η（3）-丁二烯配位是选择性生成环丁烯的关键。
A nickel-catalyzed intermolecular [2 + 2] cycloaddition of conjugated enynes with alkenes has been developed. A variety of electron-deficient alkenes as well as electronically neutral norbornene and 1-decene were applicable to this reaction. The use of conjugated enynes circumvented possible side rections, such as oligomerizations and cyclotrimerizations. The isolation of reaction intermediate complexes revealed that the eta(3)-butadienyl coordination is the key for the selective formation of cyclobutene.