EXPRESSION OF HOMEOBOX-CONTAINING GENES IN PRIMARY AND METASTATIC COLORECTAL-CANCER
EXPRESSION OF HOMEOBOX-CONTAINING GENES IN PRIMARY AND METASTATIC COLORECTAL-CANCER
复制标题
DOI：
10.1016/s0959-8049(05)80432-0
复制
发表时间：
1993-01-01
影响因子：
8.4
通讯作者：
CILLO, C
中科院分区：
文献类型：
--
作者：
DEVITA, G;BARBA, P;CILLO, C
同源框基因是编码核蛋白的基因网络，起着转录调节的作用。HOX家族的人类和小鼠同源盒基因在不同的染色体上被组织成四个簇。每个簇中的基因顺序是高度保守的，可能与它们的表达有直接关系。同源框基因最近参与了正常发育和肿瘤发生。我们分析了HOX基因在正常人结肠以及原发和转移性结直肠癌中的表达。大多数HOX基因在正常成人结肠中都是活跃的，它们的总体表达模式是该器官的特征。此外，一些HOX基因在正常结肠和肿瘤中的表达是相同的，这表明这些基因可能发挥着器官特异性的功能。相反，其他HOX基因在原发结肠癌及其肝转移中的表达发生了变化，这可能表明与结肠癌的进展有关。
Homeobox genes are a network of genes encoding nuclear proteins functioning as transcriptional regulators. Human and murine homeobox genes of the HOX family are organised in four clusters on different chromosomes. Gene order within each cluster is highly conserved, perhaps in direct relation to their expression. Homeobox genes have recently been involved in normal development and oncogenesis. We have analysed HOX gene expression in normal human colon and in primary and metastatic colorectal carcinomas. The majority of HOX genes are active in normal adult colon and their overall expression pattern is characteristic of this organ. Furthermore, the expression of some HOX genes is identical in normal and neoplastic colon indicating that these genes may exert an organ-specific function. In contrast, other HOX genes exhibit altered expression in primary colon cancers and their hepatic metastases which may suggest an association with colon cancer progression.