Dimethyl sulphoxide protects cells against polypeptide toxins and poliovirus.
Dimethyl sulphoxide protects cells against polypeptide toxins and poliovirus.
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二甲亚砜可保护细胞免受多肽毒素和脊髓灰质炎病毒的侵害。
DOI：
10.1042/bj2190935
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
S. Olsnes
中科院分区：
文献类型：
--
作者：
K. Sandvig;Helene Madshus;S. Olsnes
测试了二甲亚砜和其他冷冻保护化合物对细胞对多肽毒素和脊髓灰质炎病毒敏感性的影响。在这些影响膜流动性的化合物的存在下，细胞受到保护，免受有毒蛋白质和脊髓灰质炎病毒的侵害。获得的大量保护并不是由于毒素的结合和内吞作用减少。显然，冷冻保护化合物会干扰毒素和脊髓灰质炎病毒基因组穿过细胞膜的进入。
The effect of dimethyl sulphoxide and other cryoprotective compounds on the sensitivity of cells to polypeptide toxins and to poliovirus was tested. In the presence of these compounds, which all affect membrane fluidity, the cells were protected against the toxic proteins and against poliovirus. The large protection obtained was not due to reduced binding and endocytosis of the toxins. Apparently, the cryoprotective compounds interfere with the entry of toxins and of the poliovirus genome across the cell membrane.