Potential therapeutic agents for circulatory diseases from Bauhinia glauca Benth.subsp pernervosa. (Da Ye Guan Men)
Potential therapeutic agents for circulatory diseases from Bauhinia glauca Benth.subsp pernervosa. (Da Ye Guan Men)
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Bauhinia glauca Benth.subsp pernervosa 的循环系统疾病的潜在治疗剂。
DOI：
10.1016/j.bmcl.2015.05.089
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发表时间：
2015-08-15
影响因子：
2.7
通讯作者：
Li, Ning
中科院分区：
文献类型：
--
作者：
Tang, Yingzhan;Ling, Junhong;Li, Ning
由于血小板是致病性血栓形成的关键因素，抗血小板活性已被选定为各种循环系统疾病的治疗靶点。为了寻找潜在的治疗药物，采用生物测定法对蓝紫荆亚种进行了定向分离。pernervosa。从该草药的生物活性部分得到29个主要成分（化合物1-29）。首次对该中药具有抗血小板聚集活性的成分进行了研究。在广泛的光谱数据分析的基础上，确定了有效提取物的成分。系统评价其抗血小板聚集作用。通过化学分析和生物学分析，认为黄酮类化合物（5和18）具有显著的抗血小板聚集作用。并简要讨论了主结构与活性的关系。(C) 2015 Elsevier Ltd.版权所有。
Because of platelets as critical factor in the formation of pathogenic thrombi, anti-platelet activities have been selected as therapeutic target for various circulatory diseases. In order to find potential therapeutic agents, bioassay-directed separation of Bauhinia glauca Benth.subsp. pernervosa. (called Da Ye Guan Men as a traditional Chinese medicine) was performed to get 29 main components (compounds 1-29) from the bioactive part of this herbal. It was the first time to focus on the composition with anti-platelet aggregation activities for this traditional Chinese medicine. The constituents, characterized from the effective extract, were established on the basis of extensive spectral data analysis. Then their anti-platelet aggregation effects were evaluated systematically. On the basis of the chemical profile and biological assay, it was suggested that the flavonoid composition (5 and 18) should be responsible for the antiplatelet aggregation of the herbal because of their significant activities. The primary structure and activity relationship was also discussed briefly. (C) 2015 Elsevier Ltd. All rights reserved.