Effectiveness of erectogenic condom against semen exposure among women in Vietnam: Randomized controlled trial.
Effectiveness of erectogenic condom against semen exposure among women in Vietnam: Randomized controlled trial.
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DOI：
10.1371/journal.pone.0263503
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
Gallo MF
中科院分区：
文献类型：
--
作者：
Nguyen NC;Luong TN;Le VT;Hobbs M;Andridge R;Casterline J;Gallo MF
持续使用避孕套的一个关键障碍是它们对性快感的负面影响。虽然性快感是性行为的主要动机，也是整体性健康的一个组成部分，但大多数改善性健康的计划都是在怀孕和疾病预防的模式下运作的。一种新的避孕套，CSD 500（Futura Medical Developments; Surrey，UK），含有一种勃起药物，被开发用于健康的夫妇，通过增加阴茎的硬度、大小和勃起时间来改善性快感。我们进行了一项随机对照试验，以测试与提供标准避孕套并提供妊娠和疾病预防咨询相比，推广新型避孕套CSD 500以改善性快感是否能有效减少无避孕套性行为。我们在越南的清和省随机抽取了500对异性恋、一夫一妻制的成年夫妇，分别接受CSD 500（n = 248）和标准避孕套（n = 252）。在入组时以及2个月、4个月和6个月后，我们对女性进行了访谈，并采集了阴道液样本，以检测前列腺特异性抗原（PSA）的存在，PSA是近期精液暴露的客观生物标志物。我们在试验开始前在ClinicalTrials.gov（标识符：NCT 02934620）注册了方案。总体而言，11.0%的女性在入组时PSA阳性。干预组（6.8%）和对照组（6.7%;相对危险度，1.01; 95%置信区间，0.66-1.54）的PSA阳性随访比例没有差异。因此，我们没有发现任何证据表明，在越南，向一夫一妻制的异性恋关系中的女性推广勃起安全套会减少她们对伴侣精液的接触。这些发现可能不适用于其他人群，特别是那些无安全套性行为频率较高的人群。
A key barrier to the consistent use of condoms is their negative effect on sexual pleasure. Although sexual pleasure is a primary motivation for engaging in sex and is an integral part of overall sexual health, most programs to improve sexual health operate within a pregnancy and disease-prevention paradigm. A new condom, CSD500 (Futura Medical Developments; Surrey, UK), containing an erectogenic drug was developed for use among healthy couples to improve sexual pleasure by increasing penile firmness, size and erection duration. We conducted a randomized controlled trial to test whether promoting the novel condom CSD500 for improved sexual pleasure is effective in reducing condomless sex compared to the provision of standard condoms with counseling for pregnancy and disease prevention. We randomized 500 adult, heterosexual, monogamous couples in Thanh Hoa province, Vietnam to receive either CSD500 (n = 248) or standard condoms (n = 252). At enrollment and after 2, 4, and 6 months, we interviewed women and sampled vaginal fluid to test for the presence of prostate-specific antigen (PSA), an objective, biological marker of recent semen exposure. We registered the protocol before trial initiation at ClinicalTrials.gov (identifier: NCT02934620). Overall, 11.0% of women were PSA positive at enrollment. The proportion of follow-up visits with PSA-positivity did not differ between the intervention (6.8%) and control arms (6.7%; relative risk, 1.01; 95% confidence interval, 0.66–1.54). Thus, we found no evidence that promoting an erectogenic condom to women in a monogamous, heterosexual relationship in Vietnam reduced their exposure to their partner’s semen. These findings might not hold for other populations, especially those with a higher frequency of condomless sex.
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影响因子：
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