Increase in fluidity of membrane lipids in lymphocytes, fibroblasts and liver cells stimulated for growth
Increase in fluidity of membrane lipids in lymphocytes, fibroblasts and liver cells stimulated for growth
复制标题
刺激生长的淋巴细胞、成纤维细胞和肝细胞中膜脂的流动性增加
DOI：
10.1016/0014-5793(77)80228-7
复制
发表时间：
1977
期刊：
影响因子：
3.5
通讯作者：
M. Inbar
中科院分区：
文献类型：
--
作者：
John G. Collard;A. de Wildt;E. Oomen;J. Smeekens;P. Emmelot;M. Inbar
已经发现细胞表面参与或甚至在细胞的生长控制中起主导作用[1，2]。当体外正常的成纤维细胞彼此广泛接触时，它们停止生长[3]。通过刮擦对融合单层的机械破坏允许静止细胞移动到无细胞刮擦中。这导致生长控制接触的丧失和细胞分裂的诱导[4]。有丝分裂刺激淋巴细胞转化为母细胞是由有丝分裂原（如伴刀豆球蛋白A）与细胞表面结合引起的。与丙烯酸聚合物颗粒偶联的伴刀豆球蛋白A（Con A）不能进入细胞，引起与未偶联的Con A相同的刺激，表明只有促分裂原与细胞表面的相互作用是原始细胞形成的触发器
The cell surface has been found to participate or even to play a leading role in growth control of cells [1, 2]. When normal fibroblasts in vitro make extensive contact with each other they stop growing [3]. Mechanical disruption of a confluent monolayer by scratching allows quiescent cells to move into the cell-free scratch. This results in loss of growth controlling contact and induction of cell division [4]. Mitogenie stimulation of lymphocytes into blasts cells is caused by binding of a mitogen (eg, concanavalln A) to the cell surface. Concanavalin A (Con A) coupled to acrylic polymer particles, which cannot enter the cells, causes the same stimulation as uncoupled Con A, indicating that only the interaction of the mitogen with the cell surface is the trigger for blast formation