Ideal cardiovascular health metrics and risk of cardiovascular disease or mortality: A meta-analysis
Ideal cardiovascular health metrics and risk of cardiovascular disease or mortality: A meta-analysis
复制标题
DOI：
10.1016/j.ijcard.2016.03.210
复制
发表时间：
2016-07-01
影响因子：
3.5
通讯作者：
Fan, Yu
中科院分区：
文献类型：
--
作者：
Fang, Na;Jiang, Menglin;Fan, Yu
背景：关于理想心血管健康指标、心血管疾病 (CVD) 和死亡率的研究结果不一致。目的：通过对现有前瞻性队列研究的数据进行荟萃分析，探讨实现更多理想心血管健康指标是否与普通人群较低的 CVD 和死亡率相关。方法：从 PubMed、Embase 和 Web of Science 自成立到 2016 年 2 月进行了全面的文献检索。只有前瞻性队列研究调查理想心血管健康指标与 CVD 之间的关联，或死亡率符合条件。将最充分调整的风险比 (RR) 和相应的 95% 置信区间 (CI) 合并起来以估计相关性。结果：对涉及 12,878 名参与者的 9 项前瞻性队列研究进行了分析。荟萃分析显示，实现最理想的心血管健康指标与降低全因死亡率（RR 0.55；95% CI 0.37-0.80）、心血管死亡率（RR 0.25；95% CI 0.10-0.63）、心血管疾病（RR 0.20；95% CI 0.11-0.37）和中风（RR 0.31；95%）的风险相关。 CI 0.25-0.38）。结论：理想的心血管健康指标与全因死亡率和心血管事件呈负相关，支持使用心血管健康指标作为预测死亡率和心血管疾病风险的有用工具。 (C) 2016 Elsevier Ireland Ltd. 保留所有权利。
Background: Inconsistent findings have reported regarding ideal cardiovascular health metrics and cardiovascular disease (CVD) and mortality.Objective: To investigate whether achieving a greater number of ideal cardiovascular health metrics was associated with a lower risk of CVD and mortality in the general population by conducting a meta-analysis of data from available prospective cohort studies.Methods: A comprehensive literature search was conducted in PubMed, Embase, and Web of Science from their inception to February 2016. Only prospective cohort studies investigating the association between the ideal cardiovascular health metrics and CVD or mortality were eligible. The most-fully adjusted risk ratio (RR) and corresponding 95% confidence intervals (CI) was pooled to estimate the association.Results: Nine prospective cohort studies involving 12,878 participants were analyzed. Meta-analyses showed that achieving a greatest ideal cardiovascular health metrics was associated with lower risk of all-cause mortality (RR 0.55; 95% CI 0.37-0.80), cardiovascular mortality (RR 0.25; 95% CI 0.10-0.63), cardiovascular disease (RR 0.20; 95% CI 0.11-0.37), and stroke (RR 0.31; 95% CI 0.25-0.38).Conclusions: Ideal cardiovascular health metrics are inversely associated with all-cause mortality and cardiovascular events, supporting the use of cardiovascular health metrics as a useful tool to predictmortality and cardiovascular disease risk. (C) 2016 Elsevier Ireland Ltd. All rights reserved.