Brain injury causes a time-dependent increase in neuronotrophic activity at the lesion site.
Brain injury causes a time-dependent increase in neuronotrophic activity at the lesion site.
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DOI：
10.1126/science.7100931
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发表时间：
1982-08
期刊：
影响因子：
56.9
通讯作者：
M. Nieto‐Sampedro;E. R. Lewis;C. Cotman;M. Manthorpe;S. Skaper;G. Barbin;F. Longo;S. Varon
中科院分区：
文献类型：
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作者：
M. Nieto‐Sampedro;E. R. Lewis;C. Cotman;M. Manthorpe;S. Skaper;G. Barbin;F. Longo;S. Varon
在发育或成年大鼠的脑（内嗅皮层）中制作一个空腔，并放置一小块明胶海绵以收集分泌到伤口中的液体。用培养的交感神经元和副交感神经元测定液体的神经营养活性。结果表明，发育中或成年大鼠脑中的伤口刺激神经营养因子的积累，并且这些因子的活性在造成损伤后的最初几天内增加。
A cavity was made in the brain (entorhinal cortex) of developing or adult rats, and a small piece of Gelfoam was emplaced to collect fluid secreted into the wound. The neuronotrophic activity of the fluid was assayed with sympathetic and parasympathetic neurons in culture. The results show that wounds in the brain of developing or adult rats stimulate the accumulation of neuronotrophic factors and that the activity of these factors increases over the first few days after infliction of the damage.