Channels and transporters in salivary glands
Channels and transporters in salivary glands
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唾液腺中的通道和转运蛋白
DOI：
10.1007/s00441-010-1089-y
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发表时间：
2011
影响因子：
3.6
通讯作者：
E. Roussa
中科院分区：
文献类型：
--
作者：
E. Roussa
根据两阶段假说，初级唾液是由唾液腺泡细胞分泌的富含NaCl的血浆样等渗液，其离子组成在导管系统中发生改变。导管分泌K+和HCO 3-，并重吸收Na+和Cl-，而没有任何水分运动，从而建立低渗的最终唾液。唾液分泌依赖于位于腺泡和导管细胞的顶膜和基底膜上的几个通道和转运蛋白的协调作用。灌注腺的早期功能研究，其次是几个转运蛋白的分子克隆和突变小鼠的后续分析，极大地促进了我们对唾液和电解质分泌过程的理解。除了少数例外，大多数参与唾液分泌的关键通道和转运蛋白现已被鉴定和表征。然而，从所有这些研究中出现的图片是一个复杂的分子网络，其特征是多个转运蛋白的冗余，补偿机制以及健康和疾病的适应性变化。目前的研究是针对决定簇之间的分子相互作用以及它们受细胞外信号和细胞内介质调节的方式。这篇综述主要集中在功能和分子上最好的特点通道和转运被认为是参与跨上皮液体和电解质运输在唾液腺。
According to the two-stage hypothesis, primary saliva, a NaCl-rich plasma-like isotonic fluid is secreted by salivary acinar cells and its ionic composition becomes modified in the duct sytem. The ducts secrete K+ and HCO3- and reabsorb Na+ and Cl- without any water movement, thus establishing a hypotonic final saliva. Salivary secretion depends on the coordinated action of several channels and transporters localized in the apical and basolateral membrane of acinar and duct cells. Early functional studies in perfused glands, followed by the molecular cloning of several transport proteins and the subsequent analysis of mutant mice, have greatly contributed to our understanding of salivary fluid and the electrolyte secretion process. With a few exceptions, most of the key channels and transporters involved in salivary secretion have now been identified and characterized. However, the picture that has emerged from all these studies is one of a complex molecular network characterized by redundancy for several transport proteins, compensatory mechanisms, and adaptive changes in health and disease. Current research is directed to the molecular interactions between the determinants and the ways in which they are regulated by extracellular signals and intracellular mediators. This review focuses on the functionally and molecularly best-characterized channels and transporters that are considered to be involved in transepithelial fluid and electrolyte transport in salivary glands.
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DOI：
10.1016/s0021-9258(17)37486-0
发表时间：
1994-02
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
H. Hasegawa;T. Ma;W. Skach;M. Matthay;A. Verkman
通讯作者：
H. Hasegawa;T. Ma;W. Skach;M. Matthay;A. Verkman
影响因子：
4
作者：
A. Frigeri;M. Gropper;F. Umenishi;M. Kawashima;Dennis Brown;A. Verkman
通讯作者：
A. Frigeri;M. Gropper;F. Umenishi;M. Kawashima;Dennis Brown;A. Verkman
Cl- 通量与大鼠腮腺液体分泌相关：Cl(-)-HCO3- 交换的参与。
DOI：
10.1152/ajpgi.1992.262.3.g393
发表时间：
1992
期刊：
The American journal of physiology
影响因子：
--
作者：
Melvin,JE;Turner,RJ
通讯作者：
Turner,RJ
Clcn2 编码小鼠唾液腺导管中的超极化激活的氯离子通道。
DOI：
10.1152/ajpgi.90384.2008
发表时间：
2008
期刊：
American journal of physiology. Gastrointestinal and liver physiology
影响因子：
--
作者：
Romanenko,VictorG;Nakamoto,Tetsuji;Catalán,MarceloA;Gonzalez-Begne,Mireya;Schwartz,GeorgeJ;Jaramillo,Yasna;Sepúlveda,FranciscoV;Figueroa,CarlosD;Melvin,JamesE
通讯作者：
Melvin,JamesE
小鼠肾脏中 AE2 阴离子交换剂的免疫定位和组织特异性剪接。
DOI：
10.1681/asn.v96946
发表时间：
1998
期刊：
Journal of the American Society of Nephrology : JASN
影响因子：
--
作者：
Stuart-Tilley,AK;Shmukler,BE;Brown,D;Alper,SL
通讯作者：
Alper,SL