Helicobacter pylori infection and gastroduodenal diseases in Vietnam: a cross-sectional, hospital-based study
Helicobacter pylori infection and gastroduodenal diseases in Vietnam: a cross-sectional, hospital-based study
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DOI：
10.1186/1471-230x-10-114
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发表时间：
2010-09-30
影响因子：
2.4
通讯作者：
Moriyama, Masatsugu
中科院分区：
文献类型：
--
作者：
Nguyen, Tung L.;Uchida, Tomohisa;Moriyama, Masatsugu
背景：H.据报道，越南的幽门螺杆菌感染率很高，但H.幽门相关性胃十二指肠疾病尚未得到系统研究。此外，尽管种族和饮食相似，但北方城市河内的胃癌年龄标准化发病率高于南方城市胡志明，但这种现象的原因尚不清楚。越南H. pylori也没有被详细调查。方法：接受食管胃镜检查的个体被随机招募。H.根据培养、组织学、免疫组化、快速尿试验和血清ELISA检测结果确定pylori感染情况。消化性溃疡（PU）和胃食管反流病诊断内镜，慢性胃炎的组织学确定。H.结果：65.6%的受检者感染H.幽门。40岁以上人群感染率明显高于40岁以上人群
Background: The rate of H. pylori infection in Vietnam is reportedly high, but the spectrum of H. pylori-associated gastroduodenal diseases has not been systematically investigated. Moreover, despite the similarities of ethnicity and diet, the age-standardized incidence rate of gastric cancer in the northern city of Hanoi is higher than that in the southern city of Ho Chi Minh, but the reason for this phenomenon is unknown. The virulence of Vietnamese H. pylori has also not been investigated in detail.Methods: Individuals undergoing esophagogastroduodenoscopy were randomly recruited. H. pylori infection status was determined based on the combined results of culture, histology, immunohistochemistry, rapid urine test and serum ELISA. Peptic ulcer (PU) and gastroesophageal reflux disease was diagnosed by endoscopy, and chronic gastritis was determined histologically. H. pylori virulence factors were investigated by PCR and sequencing.Results: Among the examined patients, 65.6% were infected with H. pylori. The prevalence of infection was significantly higher in those over 40 years of age than in those aged