Hierarchical organization of cognitive memory
Hierarchical organization of cognitive memory
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DOI：
10.1098/rstb.1997.0132
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发表时间：
1997-10-29
影响因子：
6.3
通讯作者：
VarghaKhadem, F
中科院分区：
文献类型：
--
作者：
Mishkin, M;Suzuki, WA;VarghaKhadem, F
本文讨论的问题，记忆过程的组织内内侧颞叶。从内侧颞叶病理学导致的迟发性遗忘症患者中获得的证据，对这种损害对长期认知记忆的影响产生了两种相反的解释。一种观点认为，认知记忆，包括对事实和事件的记忆，是由海马体及其周围的皮层以一种单一的方式提供的;另一种观点认为，健忘症中受影响的基本功能是事件记忆，对事实材料的记忆通常表现出实质性的保留。最近的研究结果表明，在生命早期相对选择性海马损伤导致健忘症的患者可能会调和这两种观点。新的发现表明，海马体可能对事件记忆而不是事实记忆特别重要，周围的皮层区域对两者都有贡献。猴子的神经解剖学和神经行为学研究的证据支持这一建议。
This paper addresses the question of the organization of memory processes within the medial temporal lobe. Evidence obtained in patients with late-onset amnesia resulting from medial temporal pathology has given rise to two opposing interpretations of the effects of such damage on long-term cognitive memory. One view is that cognitive memory, including memory for both facts and events, is served in a unitary manner by the hippocampus and its surrounding cortices; the other is that the basic function affected in amnesia is event memory, the memory for factual material often showing substantial preservation. Recent findings in patients with amnesia resulting from relatively selective hippocampal damage sustained early in life suggest a possible reconciliation of the two views. The new findings suggest that the hippocampus may be especially important for event as opposed to fact memory with the surrounding cortical areas contributing to both. Evidence from neuroanatomical and neurobehavioural studies in monkeys is presented in support of this proposal.