Engineering Enzymes for Environmental Sustainability.
Engineering Enzymes for Environmental Sustainability.
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环境可持续性工程酶。
DOI：
10.1002/anie.202309305
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Radley E
中科院分区：
文献类型：
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作者：
Radley E
可持续催化技术的开发和实施是实现我们净零排放目标的关键。在这里，我们回顾了工程酶，重点是那些使用定向进化开发，可以部署，以提高许多过程的可持续性，并帮助保护我们的环境。高效和强大的生物催化剂已被设计用于捕获二氧化碳（CO2），并已嵌入到新的高效代谢CO2固定途径中。酶已被提炼用于生物修复，提高了它们降解有毒有害污染物的能力。生物催化回收正在获得动力，工程角质酶和PET酶被开发用于解聚丰富的塑料，聚对苯二甲酸乙二醇酯（PET）。最后，获取石油原料和化学品的生物催化方法正在扩大，使用优化的酶将植物生物质转化为生物燃料或其他高价值产品。通过这些例子，我们希望说明酶工程和生物催化如何有助于更清洁和更有效的化学工业的发展。
The development and implementation of sustainable catalytic technologies is key to delivering our net‐zero targets. Here we review how engineered enzymes, with a focus on those developed using directed evolution, can be deployed to improve the sustainability of numerous processes and help to conserve our environment. Efficient and robust biocatalysts have been engineered to capture carbon dioxide (CO2) and have been embedded into new efficient metabolic CO2fixation pathways. Enzymes have been refined for bioremediation, enhancing their ability to degrade toxic and harmful pollutants. Biocatalytic recycling is gaining momentum, with engineered cutinases and PETases developed for the depolymerization of the abundant plastic, polyethylene terephthalate (PET). Finally, biocatalytic approaches for accessing petroleum‐based feedstocks and chemicals are expanding, using optimized enzymes to convert plant biomass into biofuels or other high value products. Through these examples, we hope to illustrate how enzyme engineering and biocatalysis can contribute to the development of cleaner and more efficient chemical industry.