High prevalence of vitamin D deficiency in patients with xeroderma pigmetosum (XP)- A under strict sun-protection
High prevalence of vitamin D deficiency in patients with xeroderma pigmetosum (XP)- A under strict sun-protection
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严格防晒下的猪皮干皮病 (XP)-A 患者维生素 D 缺乏症的发生率较高
DOI：
10.1038/ejcn.2015.1
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发表时间：
2015
影响因子：
4.7
通讯作者：
Okano T.
中科院分区：
文献类型：
--
作者：
Kuwabara A;Tsugawa N;Tanaka K;Uejima Y;Ogawa J;Otao N;Yamada N;Masaki T;Nishigori C;Moriwaki S;Okano T.
结果：膳食维生素D摄入量中位数为4.1 μg/d，血清25 OHD和PTH浓度中位数分别为7.7和49.9 pg/ml。76%的患者血清25 OHD水平低于10 ng/ml，提示维生素D缺乏。肠内营养（EN）组维生素D摄入量和血清25 OHD水平明显低于口服营养（OI）组。多变量分析显示EN是血清25 OHD水平降低的显著预测因子（β系数=− 0.59，P= 0.03）。结论：维生素D缺乏在XP-A患者中非常普遍，应考虑补充维生素D以避免这些患者出现不利的骨骼后果。此外，由于皮肤产生的维生素D，膳食维生素D需要量的确定一直是决定膳食参考摄入量（DRIs）的一个困难的工作问题。XP患者的数据将为确定维生素D的DRI提供有用的信息。
Results:Median dietary intake of vitamin D was 4.1 μg/day, and the median concentrations of serum 25OHD and PTH were 7.7 and 49.9 pg/ml, respectively. In 76% of the patients, serum 25OHD level was lower than 10 ng/ml, indicating vitamin D deficiency. Vitamin D intake and serum 25OHD level were significantly lower in patients under enteral nutrition (EN) than those with oral intake (OI). Multivariate analyses revealed that EN was a significant predictor of decreased serum 25OHD level (β coefficient=− 0.59, P= 0.03).Conclusions:Vitamin D deficiency is highly prevalent in XP-A patients, and supplementation should be considered to avoid unfavorable skeletal consequences in these patients. In addition, determination of dietary vitamin D requirement has been a difficult work issue in the decision of dietary reference intakes (DRIs) because of its cutaneous production. Data from XP patients would yield useful information for the determination of DRIs for vitamin D.