Development of rod function in term born and former preterm subjects.
Development of rod function in term born and former preterm subjects.
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DOI：
10.1097/opx.0b013e3181a6a237
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发表时间：
2009-06
期刊：
影响因子：
--
通讯作者：
Moskowitz A
中科院分区：
文献类型：
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作者：
Fulton AB;Hansen RM;Moskowitz A
概述我们对视杆细胞功能正常发育的视网膜电图和心理物理学研究及其在早产儿视网膜病变中的应用。记录暗适应受试者对全视野刺激的视网膜电图（ERG）反应。视杆细胞感光敏感性，SROD，通过光转导激活的生化模型与ERG a波的拟合计算。测量用于检测视旁（10°偏心）和周边（30°偏心）视网膜中的2°斑点的暗适应心理物理阈值，并检查阈值之间的差异Δ10-30作为年龄的函数。比较了足月出生和既往早产受试者的SROD和Δ10-30。在足月出生的婴儿中，（1）SROD的正常发育增加与视杆细胞视色素、视紫红质的量成比例地变化，以及（2）与周边视网膜相比，中央视网膜中的视杆细胞介导的功能不成熟。在早产的受试者中，在活动性ROP解决后，视杆细胞感光灵敏度的缺陷持续很长时间。轻度ROP延长了中央视网膜中视杆细胞介导阈值的成熟。表征正常视杆细胞和视杆细胞介导的功能的发育为理解ROP提供了基础。
Provide an overview of some of our electroretinographic and psychophysical studies of normal development of rod function and their application to retinopathy of prematurity (ROP). Electroretinographic (ERG) responses to full-field stimuli were recorded from dark adapted subjects. Rod photoreceptor sensitivity, SROD, was calculated by fit of a biochemical model of the activation of phototransduction to the ERG a-wave. Dark adapted psychophysical thresholds for detecting 2° spots in parafoveal (10° eccentric) and peripheral (30° eccentric) retina were measured and the difference between the thresholds, Δ10-30, was examined as a function of age. SROD and Δ10-30 in term born and former preterm subjects were compared. In term born infants, (1) the normal developmental increase in SROD changes proportionately with the amount of rod visual pigment, rhodopsin, and (2) rod mediated function in central retina is immature compared to that in peripheral retina. In subjects born prematurely, deficits in rod photoreceptor sensitivity persist long after active ROP has resolved. Maturation of rod mediated thresholds in the central retina is prolonged by mild ROP. Characterization of the development of normal rod and rod mediated function provides a foundation for understanding ROP.