A review on calcium phosphate coatings produced using a sputtering process--an alternative to plasma spraying.
A review on calcium phosphate coatings produced using a sputtering process--an alternative to plasma spraying.
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DOI：
10.1016/j.biomaterials.2004.02.029
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发表时间：
2005
期刊：
影响因子：
14
通讯作者：
Y. Yang;K. Kim;J. Ong
中科院分区：
文献类型：
--
作者：
Y. Yang;K. Kim;J. Ong
在医疗器械上沉积羟基磷灰石（HA）和磷酸钙（CaP）涂层的新技术正在不断地被研究。鉴于目前有大量的实验沉积工艺，本综述将只关注使用溅射工艺生产的CaP和/或HA涂层。本文将讨论溅射CaP涂层在沉积处理前后的特性以及对某些表征涂层表面的组织响应。从文献中观察到的研究来看，目前对溅射CaP涂层的研究已经显示出一些希望，可能会消除与等离子喷涂过程相关的一些问题。溅射HA和CaP涂层可提高骨强度和初始骨整合率。然而，获得最大骨反应所需的最佳涂层性能尚未报道。因此，在生物反应评估中使用表征良好的溅射CaP和/或HA表面应充分记录，以避免有争议的结果。此外，溅射过程的未来研究应包括临床试验，以继续了解骨对不同性质的涂层种植体表面的反应，以及将溅射的HA和CaP涂层与生长因子耦合的可能性。
New promising techniques for depositing hydroxyapatite (HA) and calcium phosphate (CaP) coatings on medical devices are continuously being investigated. Given the vast number of experimental deposition process currently available, this review will focus only on CaP and/or HA coatings produced using the sputtering process. This review will discuss the characterization of sputtered CaP coatings before and after post-deposition treatments and tissue responses to some of the characterized coating surfaces. From the studies observed in the literature, current research on sputtered CaP coatings has shown some promises that may eliminate some of the problems associated with the plasma-spraying process. It has been generally accepted that sputtered HA and CaP coatings improve bone strength and initial osseointegration rate. However, optimal coating properties required to achieve maximal bone response are yet to be reported. As such, the use of well-characterized sputtered CaP and/or HA surfaces in the evaluation of biological responses should be well documented to avoid controversial results. In addition, future investigations of the sputtering process should include clinical trials, to continue the understanding of bone responses to coated-implant surfaces of different properties, and the possibility of coupling sputtered HA and CaP coatings with growth factors.