Chromosome breakage and sister chromatid exchange frequencies in scleroderma.
Chromosome breakage and sister chromatid exchange frequencies in scleroderma.
复制标题
硬皮病中的染色体断裂和姐妹染色单体交换频率。
作者：
G. Sherer;B. B. Jackson;E. Leroy
本文对3例硬皮病伴系统性疾病患者和3例正常人外周血淋巴细胞进行了染色体畸变和姐妹染色单体交换（SCE）检查。所有3例患者的染色体异常和SCE水平均显著增加。这些结果进行了讨论，在硬皮病的SCE的诊断潜力和可能的病因作用，这种疾病的细胞遗传学不稳定。
Peripheral lymphocytes from 3 scleroderma patients with systemic disease and from 3 normal controls were examined for frequencies of chromosomal aberration and sister chromatid exchange (SCE). Significant increases in the levels of chromosomal anomaly and SCE were found for all 3 patients. These results are discussed in terms of the diagnostic potential of SCE in scleroderma and the possible etiologic role of cytogenetic instability in this disease.