Heparin and related drugs: beyond anticoagulant activity.
Heparin and related drugs: beyond anticoagulant activity.
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DOI：
10.1155/2013/910743
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发表时间：
2013
期刊：
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通讯作者：
Page C
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作者：
Page C
肝素作为抗凝剂已被广泛使用了80多年。然而，现在有相当多的证据表明，肝素也具有抗炎活性，无论是实验还是临床。重要的是，在许多情况下，肝素的抗炎作用不依赖于抗凝活性，这提高了开发基于肝素的保留抗炎活性的新药的可能性。肝素通过多种机制表现出抗炎活性，包括中和阳离子介质、抑制粘附分子和抑制乙酰肝素酶，所有这些都参与白细胞募集到组织中。可以预期，进一步了解肝素的抗炎作用将导致开发用于各种临床适应症的新型抗炎药物。
Heparin has been widely used as an anticoagulant for more than 80 years. However, there is now considerable evidence that heparin also possesses anti-inflammatory activity, both experimentally and clinically. Importantly in many instances, the anti-inflammatory actions of heparin are independent of anticoagulant activity raising the possibility of developing novel drugs based on heparin that retain the anti-inflammatory activity. Heparin exhibits anti-inflammatory activities via a variety of mechanisms including neutralization of cationic mediators, inhibition of adhesion molecules, and the inhibition of heparanase, all involved in leukocyte recruitment into tissues. It is anticipated that furthering our understanding of the anti-inflammatory actions of heparin will lead to the development of novel anti-inflammatory drugs for a variety of clinical indications.