ABNORMAL MEMBRANE-CHARACTERISTICS OF ERYTHROCYTES IN RAT MODELS AND MEN WITH PREDISPOSITION TO STROKE
ABNORMAL MEMBRANE-CHARACTERISTICS OF ERYTHROCYTES IN RAT MODELS AND MEN WITH PREDISPOSITION TO STROKE
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DOI：
10.3109/10641968009037158
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发表时间：
1980-01-01
影响因子：
12.3
通讯作者：
OOSHIMA, A
中科院分区：
文献类型：
--
作者：
YAMORI, Y;NARA, Y;OOSHIMA, A
本实验观察了正常血压Wistar-Kyoto大鼠（WK）、卒中抵抗型自发性高血压大鼠（SHRSR）和卒中易感型自发性高血压大鼠（SHRSP）的红细胞膜特性。2月龄时SHRSP细胞膜对渗透压休克的敏感性高于SHRSR和WK。这种膜的脆弱性不依赖于他们的血压。亲脂性离子四苯基磷鎓的膜透性在1-mo.-老SHRSP SHRSP的这些膜特征部分依赖于胆固醇的量，SHRSP中胆固醇的量显著降低。将测定膜脆性的方法应用于人红细胞。从社区健康控制项目的约2000名居民中选择了两组人。有中风家族史组的红细胞比无中风家族史组的红细胞更不稳定。这些膜特征的检测可能为检测人类高血压或卒中易感性的遗传风险提供一种新的方法。
Erythrocyte membrane characteristics were examined in normotensive Wistar-Kyoto rats (WK), stroke-resistant spontaneously hypertensive rats (SHRSR) and stroke-prone SHR (SHRSP). The membrane of SHRSP was more labile against osmotic shock than that of SHRSR or WK at the age of 2 mo. This membrane fragility was not dependent on their blood pressure. The membrane permeability of lipophilic ion, tetraphenylphosphonium, was increased in 1-mo.-old SHRSP. These membrane characteristics in SHRSP were partially dependent on the amount of cholesterol, which was significantly decreased in SHRSP. The method of determining the membrane fragility was applied to human erythrocytes. Two groups of people were selected from about 2000 inhabitants of a community health control program. The erythrocytes from the group with stroke in their family history were more labile than erythrocytes from the corresponding group without stroke in their family history. The examination of these membrane characteristics may give a new method for detecting a genetic risk of hypertension or stroke-proneness in human.