Oral contraceptives and gender affect protein S status.
Oral contraceptives and gender affect protein S status.
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DOI：
10.1182/blood.v69.2.692.bloodjournal692692
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发表时间：
1987-02
期刊：
影响因子：
20.3
通讯作者：
LM Boerger;PC Morris;G. R. Thurnau;C. T. Esmon
中科院分区：
文献类型：
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作者：
LM Boerger;PC Morris;G. R. Thurnau;C. T. Esmon
蛋白S是一种血浆蛋白，作为活化蛋白C抗凝作用的辅助因子。先天性蛋白S缺乏症常与血栓栓塞性疾病有关。在怀孕期间，蛋白S的功能和抗原水平降低;蛋白S状态的这种变化可能导致有时在怀孕期间发生的血栓栓塞并发症。在某些患者中，口服避孕药的使用也与血栓性并发症有关。在这项研究中，蛋白S状态测定21名妇女服用口服避孕药，并与21名妇女没有服用口服避孕药和21名男子进行了比较。结果显示，服用口服避孕药的女性的总蛋白S（24.3 +/- 3.6微克/毫升;平均值+/- SD）显著低于未服用口服避孕药的女性（28.6 +/- 3.9微克/毫升）（P <0.005）。男性的蛋白S水平（30.9 +/- 3.9微克/毫升，P <0.01）显著高于年龄匹配的未服用口服避孕药的女性。在血浆中，游离（功能活性）蛋白S和与C4 b结合蛋白复合的蛋白S（功能无活性）之间存在平衡。C4 b结合蛋白的平均水平在三组之间基本相同，但游离蛋白S的水平有显着差异，反映了不同的总蛋白S抗原水平。此外，我们发现炎症显著升高C4 b结合蛋白水平，并可能导致游离蛋白S水平进一步显著降低。这些数据表明，血浆蛋白S水平受激素状态和炎症的显著影响。
Protein S is a plasma protein that serves as a cofactor for the anticoagulant effects of activated protein C. Congenital protein S deficiency is often associated with thromboembolic disease. During pregnancy a decrease in the functional and antigenic levels of protein S occurs; this change in protein S status may contribute to the thromboembolic complications that sometimes occur during pregnancy. In certain patients, oral contraceptive use has also been associated with thrombotic complications. In this study, protein S status was determined in 21 women taking oral contraceptives and compared with that of 21 women not taking oral contraceptives and that of 21 men. The results show that women taking oral contraceptives have significantly lower total protein S (24.3 +/- 3.6 micrograms/mL; mean +/- SD) than women not taking oral contraceptives (28.6 +/- 3.9 micrograms/mL) (P less than .005). Men had significantly higher protein S levels (30.9 +/- 3.9 micrograms/mL, P less than .01) than age-matched women not taking oral contraceptives. In plasma, an equilibrium exists between free (functionally active) protein S and protein S complexed to C4b-binding protein, which is functionally inactive. The mean levels of C4b-binding protein were essentially the same among the three groups, but the levels of free protein S were significantly different and reflected different total protein S antigen levels. Additionally, we found that inflammation significantly elevated C4b-binding protein levels and could result in a further significant decrease in free protein S levels. These data indicate that plasma protein S levels are significantly affected by hormonal status and inflammation.