Mathematical modelling of mechano-electric feedback in cardiomyocytes

Mathematical modelling of mechano-electric feedback in cardiomyocytes
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心肌细胞机电反馈的数学模型

DOI:
10.1515/1569398041974941
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发表时间:
2004
影响因子:
7.8
通讯作者:
V. Markhasin
V. Markhasin
中科院分区:
数学1区
文献类型:
--
作者:
O. Solovyova;N. Vikulova;P. Konovalov;P. Kohl;V. Markhasin

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我们早期开发的数学模型的电和机械活动的心肌,它考虑到直接耦合和反馈之间的兴奋和收缩。在本文中,在该模型的框架下,我们发现的条件下,突然缩短和拉伸的心脏准备可以引起额外的动作电位,因此异常变形可以心律失常的来源。在该模型的框架下,我们建立了可能的机制Anrep现象,反映了心肌收缩和血管阻力之间的关系,在完整的心脏。
We earlier developed the mathematical model of electrical and mechanical activity in myocardium, which takes into account both direct coupling and feedback between excitation and contraction. In this paper, in the framework of the model we found conditions under which both the abrupt shortening and stretch of cardiac preparation can cause extra action potentials and hence anomalous deformations can be arrhythmia sources. In the framework of the model, we establish possible mechanisms underlying the Anrep phenomenon that reflects a relationship between myocardium contraction and vascular resistance in the intact heart.
机械敏感电流在心律失常产生中的作用的模型研究。
DOI: 10.1006/jtbi.1997.0538
发表时间: 1998
影响因子: 2
作者:
Rice,JJ;Winslow,RL;Dekanski,J;McVeigh,E
通讯作者: McVeigh,E
骨骼和心肌收缩激活:原肌球蛋白“摇滚”。
DOI: --
发表时间: 2001
期刊: News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society
影响因子: --
作者:
Gordon,AM;Regnier,M;Homsher,E
通讯作者: Homsher,E