IMPAIRED PULMONARY-FUNCTION AS A RISK FACTOR FOR MORTALITY
IMPAIRED PULMONARY-FUNCTION AS A RISK FACTOR FOR MORTALITY
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DOI：
10.1093/oxfordjournals.aje.a113385
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发表时间：
1982-01-01
影响因子：
5
通讯作者：
CHEN, CJ
中科院分区：
文献类型：
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作者：
BEATY, TH;COHEN, BH;CHEN, CJ
对1976年至1981年2539名印度人死亡率的前瞻性随访资料表明，肺功能损害是短期死亡率的危险因素，即使考虑到年龄、性别和吸烟等危险因素。受损个体（用力呼气量小于用力肺活量的68%）的预测风险曲线在所有年龄段的所有种族性别类别中始终较高。使用比例风险模型进行的生存分析显示，与肺功能良好的患者相比，肺功能不良的患者估计生存率下降更快，调整了年龄，种族和吸烟影响。这些观察结果与肺功能损害是几种非呼吸系统和呼吸系统疾病发病率和死亡率的风险因素的概念一致，并且它通过促进不同器官系统中的各种致病机制而起作用。
Prospective follow-up information obtained between 1976 and 1981 on mortality among 2539 indiiduals showed that pulmonary function impairment is a risk factor for short-term mortality, even when risk factors such as age, sex, and smoking are considered. Predicted risk curves for impaired individuals (those with forced expiratory volume in 1 less than 68% of forced vital capacity) are consistently higher among all race-sex categories over all ages. Survival analysis using the proportional hazards model shows a steeper decline in estimated survival among individuals with poor pulmonary function compared to those with good pulmonary function, adjusted for age, race and smoking effects. These observations are consistent with the concept that impairment of pulmonary function is a risk factor for morbidity and mortality from several nonrespiratory and respiratory diseases and it acts by contributing to various pathogenic mechanisms in different organ systems.