Seroprevalence of SARS-CoV-2-Specific IgG Antibodies Among Adults Living in Connecticut: Post-Infection Prevalence (PIP) Study.
Seroprevalence of SARS-CoV-2-Specific IgG Antibodies Among Adults Living in Connecticut: Post-Infection Prevalence (PIP) Study.
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DOI：
10.1016/j.amjmed.2020.09.024
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发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Krumholz HM
中科院分区：
文献类型：
--
作者：
Mahajan S;Srinivasan R;Redlich CA;Huston SK;Anastasio KM;Cashman L;Massey DS;Dugan A;Witters D;Marlar J;Li SX;Lin Z;Hodge D;Chattopadhyay M;Adams MD;Lee C;Rao LV;Stewart C;Kuppusamy K;Ko AI;Krumholz HM
血清流行率研究可以估计一般人群中患有严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 抗体的人的百分比；然而，大多数现有报告都使用了方便样本，这可能会使他们的估计产生偏差。我们寻找了康涅狄格州居民的代表性样本，年龄≥18岁，居住在非聚集环境中，他们在2020年6月4日至6月23日期间完成了一项调查，并在2020年6月10日至7月29日期间接受了SARS-CoV-2特异性免疫球蛋白G (IgG)抗体的血清学检测。我们还对非西班牙裔黑人和西班牙裔亚人群进行了过度抽样。我们估计了该人群中 SARS-CoV-2 特异性 IgG 抗体的血清流行率、症状性疾病的流行率以及自我报告的风险缓解行为遵守情况。在州一级纳入的 567 名受访者（平均年龄 50 [± 17] 岁；53% 女性；75% 非西班牙裔白人）中，23 名受访者 SARS-CoV-2 特异性抗体检测呈阳性，导致加权血清阳性率为 4.0（90% 置信区间 [CI] 2.0-6.0）。过采样的非西班牙裔黑人和西班牙裔人群的加权血清流行率分别为 6.4% (90% CI 0.9-11.9) 和 19.9% (90% CI 13.2-26.6)。大多数州一级的受访者报告了以下风险缓解行为：73% 的人避开公共场所，75% 的人避免家人或朋友的聚会，97% 的人至少在部分时间佩戴口罩。这些估计表明，康涅狄格州绝大多数人缺乏针对 SARS-CoV-2 的抗体，并且存在种族和民族差异。康涅狄格州居民需要继续遵守风险缓解行为，以防止该地区出现 COVID-19 死灰复燃的情况。
A seroprevalence study can estimate the percentage of people with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in the general population; however, most existing reports have used a convenience sample, which may bias their estimates. We sought a representative sample of Connecticut residents, ages ≥18 years and residing in noncongregate settings, who completed a survey between June 4 and June 23, 2020, and underwent serology testing for SARS-CoV-2-specific immunoglobulin G (IgG) antibodies between June 10 and July 29, 2020. We also oversampled non-Hispanic black and Hispanic subpopulations. We estimated the seroprevalence of SARS-CoV-2-specific IgG antibodies and the prevalence of symptomatic illness and self-reported adherence to risk-mitigation behaviors among this population. Of the 567 respondents (mean age 50 [± 17] years; 53% women; 75% non-Hispanic white individuals) included at the state level, 23 respondents tested positive for SARS-CoV-2-specific antibodies, resulting in weighted seroprevalence of 4.0 (90% confidence interval [CI] 2.0-6.0). The weighted seroprevalence for the oversampled non-Hispanic black and Hispanic populations was 6.4% (90% CI 0.9-11.9) and 19.9% (90% CI 13.2-26.6), respectively. The majority of respondents at the state level reported following risk-mitigation behaviors: 73% avoided public places, 75% avoided gatherings of families or friends, and 97% wore a facemask, at least part of the time. These estimates indicate that the vast majority of people in Connecticut lack antibodies against SARS-CoV-2, and there is variation by race and ethnicity. There is a need for continued adherence to risk-mitigation behaviors among Connecticut residents to prevent resurgence of COVID-19 in this region.
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