Electrical activity in the prefrontal cortex specific to no-go reaction of conditioned hand movement with colour discrimination in the monkey
Electrical activity in the prefrontal cortex specific to no-go reaction of conditioned hand movement with colour discrimination in the monkey
复制标题
猴子前额叶皮层的电活动特定于条件性手部运动与颜色辨别的不进行反应
作者：
K. Sasaki;H. Gemba
摘要：训练猴子在反应时间任务中执行手部动作，区分正（行）和负（不行）光信号，并使用长期植入的皮层电极记录和分析各个皮层区域的场电位。正如之前报道的，前额叶、前运动和运动皮质等区域与简单的视觉启动、反应时手部运动相关。发现主沟背侧岸的尾部在辨别过程中的禁行试验中被特别激活，并显示出相对尖锐的表面负电势、深度正电势。电位出现的潜伏期为 110-150 毫秒，比围棋试验中的运动开始早 150-210 毫秒。随着通过和不通过信号的逆转，发现这种电位仅在不通过试验中被记录，无论刺激使用的颜色如何。这表明主沟背侧的活动与不执行运动的判断和/或运动执行的抑制有关。
SummaryMonkeys were trained to perform hand movements in a reaction time task with discrimination between positive (go) and negative (no-go) light signals, and field potentials in various cortical areas were recorded and analysed with chronically implanted cortical electrodes. As previously reported, areas such as the prefrontal, premotor and motor cortices were active in association with simple visually-initiated, reaction-time hand movements. The caudal part of the dorsal bank of the principal sulcus was found to be activated specifically on no-go trials during discrimination, and revealed a relatively sharp surface-negative, depth-positive potential. The potential appeared at a latency of 110–150 ms, which was 150–210 ms earlier than the movement onset on go trials. With reversal of the go and no-go signals, this potential was found to be recorded only on no-go trials, irrespective of the colour used for the stimulus. It is suggested that the activity in the dorsal bank of the principal sulcus is related to the judgement not to execute the movement and/or the suppression of motor execution.