Tumor associated macrophages and neutrophils in cancer
Tumor associated macrophages and neutrophils in cancer
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DOI：
10.1016/j.imbio.2013.06.003
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发表时间：
2013-11-01
期刊：
影响因子：
2.8
通讯作者：
Jaillon, Sebastien
中科院分区：
文献类型：
--
作者：
Galdiero, Maria Rosaria;Bonavita, Eduardo;Jaillon, Sebastien
肿瘤微环境是一个复杂的框架，其中骨髓细胞在塑造从肿瘤发生到转移的癌症发展过程中发挥着重要作用。免疫细胞是肿瘤微环境的关键参与者，它们可以促进或抑制癌症的形成和发展。可塑性是骨髓细胞，特别是单核细胞-巨噬细胞谱系的一个广泛接受的标志。它包括响应不同信号而显示多种激活状态的能力，经典 M1 或替代 M2 巨噬细胞代表了此功能的范例。长期以来，中性粒细胞一直被视为终末分化的效应细胞，在炎症的急性期和对微生物的抵抗力中发挥着重要作用。最近的证据对这种有限的观点提出了质疑，表明中性粒细胞可以与不同的细胞群相互作用并产生大量的细胞因子和效应分子。因此，巨噬细胞和中性粒细胞都参与调节各种炎症情况（包括癌症）的先天性和适应性免疫反应。 (C) 2013 爱思唯尔有限公司。版权所有。
The tumor microenvironment is a complex framework, in which myeloid cells play important roles in sculpting cancer developinent from tumor initiation to metastasis. Immune cells are key participants of the tumor microenvironment where they can promote or inhibit cancer formation and development. Plasticity is a widely accepted hallmark of myeloid cells and in particular of the monocyte-macrophage lineage. It includes the ability to display a wide spectrum of activation states in response to distinct signals and classical M1 or alternative M2 macrophages represent a paradigm of this feature. Neutrophils have long been viewed as terminally differentiated effector cells, playing a major role during the acute phase of inflammation and resistance against microbes. Recent evidence questioned this limited point of view, indicating that neutrophils can interact with distinct cell populations and produce a wide number of cytokines and effector molecules. Therefore, macrophages and neutrophils are both integrated in the regulation of the innate and adaptive immune responses in various inflammatory situations, including cancer. (C) 2013 Elsevier GmbH. All rights reserved.