Deficiency of T cell mediated regulation of anti-DNA production in systemic lupus erythematosus.
Deficiency of T cell mediated regulation of anti-DNA production in systemic lupus erythematosus.
复制标题
系统性红斑狼疮中 T 细胞介导的抗 DNA 产生调节的缺陷。
作者：
J. Clough;S. Frank;L. Calabrese
从正常人和系统性红斑狼疮（SLE）患者分离的B细胞可被美洲商陆有丝分裂原刺激产生IgM抗DNA。正常而非SLE的同种异体T细胞消除了这种反应。正常但非SLE自体T细胞促进从IgM到IgG抗DNA产生的转换。SLE的特征在于至少两种类型的免疫调节异常：T抑制因子功能缺陷和IgM至IgG抗体缺陷。
Isolated B cells from normal subjects and patients with systemic lupus erythematosus (SLE) could be stimulated to produce IgM anti-DNA with pokeweed mitogen. Normal but not SLE allogeneic T cells abrogated this response. Normal but not SLE autologous T cells promoted a switch from IgM to IgG anti-DNA production. SLE is characterized by at least two types of immunoregulatory abnormalities: a defect in T suppressor function and a defect in the IgM to IgG switchover.