Behavioural relevance of variation in white matter microstructure
Behavioural relevance of variation in white matter microstructure
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DOI：
10.1097/wco.0b013e32833b7631
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发表时间：
2010-08-01
影响因子：
4.8
通讯作者：
Johansen-Berg, Heidi
中科院分区：
文献类型：
--
作者：
Johansen-Berg, Heidi
综述目的：近年来，利用弥散加权磁共振成像（DWI）研究人脑中的白色物质结构的研究迅速增加。本文综述了白色物质结构的个体间差异与行为相关的证据。最近的发现白色物质在整个生命周期中的成熟或恶化与特定认知技能的发展或下降有关。此外，在健康成年人群中发现了白色物质解剖结构与能力之间的年龄无关关系。这种关系可能部分由遗传学决定，但也可以由experience.SummaryIndividual differences在白色物质解剖，可见使用DWI，行为的后果。这种关系的发现突出了识别成像生物标志物的潜力，这些生物标志物可以预测患者对特定干预措施的反应。
Purpose of reviewThere has been a rapid increase in studies using diffusion-weighted magnetic resonance imaging (DWI) to interrogate white matter structure in the human brain. This review considers the evidence that interindividual variation in white matter structure is behaviourally relevant.Recent findingsMaturation or deterioration of white matter throughout the lifespan relates to development or decline in specific cognitive skills. In addition, age-independent relationships between white matter anatomy and ability are found in healthy adult populations. Such relationships may in part be determined by genetics but can also be driven by experience.SummaryIndividual differences in white matter anatomy, visible using DWI, have consequences for behaviour. The discovery of such relationships highlights the potential for identification of imaging biomarkers that could predict how well patients will respond to specific interventions.