Lack of association of polymorphisms of the lymphotoxin α gene with myocardial infarction in Japanese
Lack of association of polymorphisms of the lymphotoxin α gene with myocardial infarction in Japanese
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DOI：
10.1007/s00109-004-0556-x
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发表时间：
2004-07-01
影响因子：
4.7
通讯作者：
Yokota, M
中科院分区：
文献类型：
--
作者：
Yamada, A;Ichihara, S;Yokota, M
血管炎症在心肌梗死（MI）的发生发展中起重要作用。光氧素α（LTA）是一种在免疫系统和炎症反应调节中具有多种功能的细胞因子。本研究的目的是检测日本男性和女性中LTA基因多态性是否与MI风险相关。对LTA基因252 A->G和804 C->A多态性与MI患病率进行病例对照关联研究。研究人群包括3，689名无关的日本个体（2，486名男性，1，203名女性），包括1891名MI患者（1，493名男性，398名女性）和1798名对照受试者（993名男性，805名女性）。在对照组中，257例（108例男性，149例女性）无冠状动脉疾病（CAD）的传统危险因素，被定义为低fisk对照。两个多态性的基因型确定与基于荧光的等位基因特异性DNA引物检测系统。在所有研究对象中，252 A-->G和804 C-->A多态性存在连锁不平衡。与对照组或低危对照组相比，在男性或女性中均未检测到任何多态性与MI的相关性。然而，在隐性遗传模型中，这两种多态性均与MI男性和非MI男性2型糖尿病的患病率相关。未检测到多态性与CAD的其他传统危险因素之间的关联。因此，LTA基因似乎不是日本男性或女性MI的易感基因座，尽管它可能影响日本男性对2型糖尿病的易感性。
Vascular inflammation plays an important role in the development of myocardial infarction (MI). Lymphotoxin alpha (LTA) is a cytokine with multiple functions in regulation of the immune system and inflammatory reactions. The aim of this study was to examine whether polymorphisms of the LTA gene are associated with the risk of MI in Japanese men and women. A case-control association study was performed for the 252A-->G and 804C-->A polymorphisms of the LTA gene and the prevalence of MI. The study population comprised 3,689 unrelated Japanese individuals (2,486 men, 1,203 women), including 1891 patients with MI (1,493 men, 398 women) and 1798 control subjects (993 men, 805 women). Among the control subjects 257 individuals (108 men, 149 women) who had none of the conventional risk factors for coronary artery disease (CAD) were defined as low-fisk controls. Genotypes for the two polymorphisms were determined with a fluorescence-based allele-specific DNA primer assay system. Among all study subjects the 252A-->G and 804C-->A polymorphisms exhibited linkage disequilibrium. No association of either polymorphism with MI was detected in men or in women in comparisons with total control or low-risk control subjects. However, each of the two polymorphisms was associated with the prevalence of type 2 diabetes mellitus both in men with MI and in those without MI in a recessive genetic model. No association was detected between the polymorphisms and other conventional risk factors for CAD. The LTA gene thus does not appear to be a susceptibility locus for MI in Japanese men or women, although it might affect susceptibility to type 2 diabetes in Japanese men.