Synthesis of rigidly-linked vancomycin dimers and their in vivo efficacy against resistant bacteria
Synthesis of rigidly-linked vancomycin dimers and their in vivo efficacy against resistant bacteria
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DOI：
10.1039/b613319c
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发表时间：
2007-01-01
影响因子：
4.9
通讯作者：
Arimoto, Hirokazu
中科院分区：
文献类型：
--
作者：
Lu, Jun;Yoshida, Osamu;Arimoto, Hirokazu
描述了一种新的和有效的制备二聚体万古霉素的途径，并且二聚体在小鼠感染模型中表现出优异的抗菌活性。
A novel and efficient avenue for the preparation of dimeric vancomycins is described, and the dimers exhibited excellent antibacterial activities in the murine infection model.