A comparison of the local anaesthetic‐, “quinidine‐like”‐ and adrenergic β‐blocking‐activities of five β‐receptor antagonists
A comparison of the local anaesthetic‐, “quinidine‐like”‐ and adrenergic β‐blocking‐activities of five β‐receptor antagonists
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五种 β 受体拮抗剂的局麻药、“奎尼丁样”和肾上腺素能 β 阻滞活性的比较
DOI：
10.1111/j.2042-7158.1970.tb08520.x
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发表时间：
1970
期刊：
影响因子：
--
通讯作者：
W. Davis
中科院分区：
文献类型：
--
作者：
W. Davis
普萘洛尔、普萘洛尔、INPEA、MJ 1999和MJ 1998在浸润麻醉和运动神经末梢评估时显示出局部麻醉活性，但只有普萘洛尔、普萘洛尔和INPEA对膈运动神经显示出局部麻醉活性。所有β-肾上腺素能阻滞剂均表现出“奎尼丁样”活性，局部麻醉和“奎尼丁样”活性之间似乎存在密切相关性，不能扩展至包括肾上腺素能β-受体拮抗作用。
Propranolol, pronethalol, INPEA, MJ1999 and MJ1998 exhibit local anaesthetic activity when assessed by infiltration anaesthesia and at motor nerve endings but only propranolol, pronethalol and INPEA exhibit local anaesthetic activity on the phrenic motor nerve. All the β‐adrenergic blocking agents exhibit a “quinidine‐like” activity and there appears to be a close correlation between local anaesthetic and “quinidine‐like” activities, which cannot be extended to include adrenergic β‐receptor antagonism.