Antipain, but not cycloheximide, suppresses radiation transformation when present for only one day at five days post-irradiation.
Antipain, but not cycloheximide, suppresses radiation transformation when present for only one day at five days post-irradiation.
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抗痛药（而非放线菌酮）仅在照射后五天内存在一天即可抑制放射转化。
DOI：
10.1093/carcin/3.9.1093
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发表时间：
1982
期刊：
影响因子：
4.7
通讯作者：
Kennedy,AR
中科院分区：
文献类型：
--
作者：
Kennedy,AR
先前已观察到蛋白酶抑制剂在体外抑制辐射转化。在此报道的实验中，观察到在辐射后五天用蛋白酶抑制剂抗痛剂治疗 24 小时足以显着抑制辐射转化。使用放线菌酮（一种蛋白质合成抑制剂）进行的类似实验表明，这种代谢抑制剂在 X 射线照射后立即存在时可以抑制辐射转化，但在辐射后五天的一天内则不能抑制辐射转化。这些结果表明，抗痛剂正在抑制响应 X 射线而发生的正在进行的细胞过程。
It has previously been observed that protease inhibitors suppress radiation transformationin vitro. In the experiments reported here, it was observed that a 24 h treatment with the protease inhibitor antipain at five days post-irradiation was sufficient to significantly suppress radiation transformation. Comparable experiments performed with cydoheximide, an inhibitor of protein synthesis, showed that this metabolic inhibitor could suppress radiation transformation when present immediately following the X-ray exposure but not when present for one day at five days post-irradiation. These results suggest that antipain is suppressing an ongoing cellular process occurring in response to X-irradiation.