Cyclic loading on the red cell membrane in a shear flow: a possible cause of hemolysis.
Cyclic loading on the red cell membrane in a shear flow: a possible cause of hemolysis.
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剪切流中红细胞膜上的循环负载：溶血的可能原因。
DOI：
10.1115/1.3138541
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
M. Sugihara
中科院分区：
文献类型：
--
作者：
H. Niimi;M. Sugihara
分析了单个人红细胞在高剪切流中所受的流体力。采用二维椭圆微胶囊作为变形红细胞的模型，数值计算了细胞膜两侧的剪切力分布。从理论上证明了细胞膜在绕内部旋转运动下承受非稳态循环载荷。通过反复加载连续移动的细胞膜来检查导致血细胞损伤的机制。
The fluid force acting on single human red cells in a high shear flow was analyzed. A two-dimensional elliptical microcapsule as a model of the deformed red cells was adopted to numerically calculate the distributions of the shear forces on both sides of the cell membrane. It is theoretically shown that the cell membrane undergoes an unsteady cyclic loading under the rotational motion around the interior. The mechanism leading to blood cell trauma is examined by repeatedly loading the continuously moving cell membrane.