Brain haemosiderin in older people: pathological evidence for an ischaemic origin of magnetic resonance imaging ( MRI) microbleeds
Brain haemosiderin in older people: pathological evidence for an ischaemic origin of magnetic resonance imaging ( MRI) microbleeds
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DOI：
10.1111/nan.12062
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发表时间：
2014-04-01
影响因子：
5
通讯作者：
Ince, P. G.
中科院分区：
文献类型：
--
作者：
Janaway, B. M.;Simpson, J. E.;Ince, P. G.
磁共振成像（MRI）脑微出血（CMB）是由铁磁性含铁血黄素铁引起的，推测其来源于红细胞外渗。光学显微镜下经常发现老化脑的含铁血黄素病灶，从单个晶体到更大的，主要是血管周围的聚集体。这些发现之间的病理和放射学的关系是没有resolved.MethodsHaemosiderin沉积和血管病理在壳核进行了量化，在200脑捐赠给人口代表医学研究理事会认知功能和老龄化研究。通过免疫组织化学在具有最高（n=20）和最低（n=20）水平壳核含铁血黄素的脑中评估神经胶质增生和组织完整性的分子标记物。分析了含铁血黄素计数与退行性和血管性脑病理学、临床数据和血色病（HFE）基因H63D基因型之间的关联。结果大壳核含铁血黄素与小血管缺血的壳核指数显著相关（微梗死，P
IntroductionMagnetic resonance imaging (MRI) cerebral microbleeds (CMB) arise from ferromagnetic haemosiderin iron assumed to derive from extravasation of erythrocytes. Light microscopy of ageing brain frequently reveals foci of haemosiderin from single crystalloids to larger, predominantly perivascular, aggregates. The pathological and radiological relationship between these findings is not resolved.MethodsHaemosiderin deposition and vascular pathology in the putamen were quantified in 200 brains donated to the population-representative Medical Research Council Cognitive Function and Ageing Study. Molecular markers of gliosis and tissue integrity were assessed by immunohistochemistry in brains with highest (n=20) and lowest (n=20) levels of putamen haemosiderin. The association between haemosiderin counts and degenerative and vascular brain pathology, clinical data, and the haemochromatosis (HFE) gene H63D genotype were analysed. The frequency of MRI CMB in 10 cases with highest and lowest burden of putamen haemosiderin, was compared using post mortem 3T MRI.ResultsGreater putamen haemosiderin was significantly associated with putaminal indices of small vessel ischaemia (microinfarcts, P