Neuropeptide Y receptor-specifically modulates human neutrophil function
Neuropeptide Y receptor-specifically modulates human neutrophil function
复制标题
DOI：
10.1016/j.jneuroim.2008.01.012
复制
发表时间：
2008-03-01
影响因子：
3.3
通讯作者：
von Hoersten, Stephan
中科院分区：
文献类型：
--
作者：
Bedoui, Sammy;Kromer, Andreas;von Hoersten, Stephan
尽管越来越多的证据强调了NPY在免疫系统中的作用，但令人惊讶的是，人们对它改变人类白细胞功能的能力知之甚少。因此，我们着手研究在新鲜分离的人中性粒细胞的NPY受体的表达和功能的影响。我们的研究结果不仅首次证明了人类中性粒细胞上存在特异性NPY受体，而且还揭示了这些受体如何差异调节中性粒细胞的关键功能，如细菌的吞噬作用以及活性氧的释放。(C)2008 Elsevier B.V.保留所有权利。
Despite a continuously growing body of evidence highlighting the role of NPY in the immune system, surprisingly little is known about its ability to alter human leukocyte function. We therefore set out to examine NPY receptor expression and functional effects of NPY in freshly isolated human neutrophils. Our results not only demonstrate for the first time the presence of specific NPY receptors on human neutrophils, but also unveil of how these receptors differentially modulate critical functions of neutrophils such as phagocytosis of bacteria as well as the release of reactive oxygen species. (C) 2008 Elsevier B.V. All rights reserved.