One-pot synthesis, characterisation and kinetic stability of novel side-bridged pentaazamacrocyclic copper(ii) complexes
One-pot synthesis, characterisation and kinetic stability of novel side-bridged pentaazamacrocyclic copper(ii) complexes
复制标题
新型侧桥五氮杂大环铜(ii)配合物的一锅法合成、表征及动力学稳定性
作者：
Betts H
单步合成方案报告了新的大环铜（II）配合物，将哌嗪单元在配体骨架。同步辐射X-射线结构测定证实了铜（II）的协调几何形状在固体状态下，作为扭曲的正方形金字塔与氯化物占据的轴向位置以上的N4配体平面。DFT计算，电化学研究和紫外/维斯在生物介质中的调查都证实，在这一类的化合物具有很高的稳定性，并比较以及在热力学和动力学方面与无处不在的Cu（II）cyclam化合物，因此，相关的未来使用作为合成支架的结合，运输和跟踪铜离子在体外。
Single-step synthetic protocols are reported for novel macrocyclic copper(II) complexes incorporating a piperazine unit in the ligand backbone. Synchrotron X-ray structure determination confirmed the copper(II) coordination geometry in the solid state as distorted square pyramidal with chloride occupying the axial position above the N4 ligand plane. DFT calculations, electrochemical studies and UV/vis investigations in biological media all confirmed that compounds in this class have high stability, and compare well in both thermodynamic and kinetic terms with the ubiquitous Cu(II) cyclam compounds, and are therefore of relevance for future use as synthetic scaffolds for the binding, transport and tracing of copper ions in vitro.