Regeneration of meniscus cartilage in a knee treated with percutaneously implanted autologous mesenchymal stem cells
Regeneration of meniscus cartilage in a knee treated with percutaneously implanted autologous mesenchymal stem cells
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DOI：
10.1016/j.mehy.2008.06.042
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发表时间：
2008-12-01
影响因子：
4.7
通讯作者：
Karli, David
中科院分区：
文献类型：
--
作者：
Centeno, Christopher J.;Busse, Dan;Karli, David
间充质干细胞是在多种人体组织中发现的多能细胞，包括骨髓、滑膜组织和脂肪组织。它们已被证明可以分化为骨、软骨、肌肉和脂肪组织，代表了再生医学中一种可能有前途的新疗法。由于其多能能力，间充质干细胞 (MSC) 谱系已成功用于动物模型中的关节软骨再生和人体模型中的骨骼再生。通过经皮引入间充质干细胞 (MSC) 来再生关节软骨是一个具有重大科学和治疗意义的课题。目前骨关节炎软骨损伤的治疗主要集中于外科手术，例如关节镜清创术、微骨折和软骨移植/移植。事实证明，这些手术的效果不如预期，具有侵入性，并且通常需要较长的恢复时间。我们假设可以从髂嵴采集自体间充质干细胞，使用患者自身的血小板裂解物生长因子进行扩增，然后成功植入成人膝盖以增加软骨体积。我们发表了一篇综述，重点介绍了该领域细胞和再生医学的发展 间充质干细胞疗法，以及成功收获、扩增自体间充质干细胞并将其移植到成人膝盖中导致半月板软骨体积增加的案例。 (C) 2008 Elsevier Ltd. 保留所有权利。
Mesenchymal stem cells are pluripotent cells found in multiple human tissues including bone marrow, synovial tissues, and adipose tissues. They have been shown to differentiate into bone, cartilage, muscle, and adipose tissue and represent a possible promising new therapy in regenerative medicine. Because of their multi-potent capabilities, mesenchymal stem cell (MSC) lineages have been used successfully in animal models to regenerate articular cartilage and in human models to regenerate bone.The regeneration of articular cartilage via percutaneous introduction of mesenchymal stem cells (MSC's) is a topic of significant scientific and therapeutic interest. Current treatment for cartilage damage in osteoarthritis focuses on surgical interventions such as arthroscopic debridement, microfracture, and cartilage grafting/ transplant. These procedures have proven to be less effective than hoped, are invasive, and often entail a prolonged recovery time.We hypothesize that autologous mesenchymal stem cells can be harvested from the iliac crest, expanded using the patient's own growth factors from platelet lysate, then successfully implanted to increase cartilage volume in an adult human knee.We present a review highlighting the developments in cellular and regenerative medicine in the arena mesenchymal stem cell therapy, as well as a case of successful harvest, expansion, and transplant of autologous mesenchymal stem cells into an adult human knee that resulted in an increase in meniscal cartilage volume. (C) 2008 Elsevier Ltd. All rights reserved.