Disease activity and health status in rheumatoid arthritis: a case-control comparison between Norway and Lithuania
Disease activity and health status in rheumatoid arthritis: a case-control comparison between Norway and Lithuania
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DOI：
10.1136/ard.62.3.231
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发表时间：
2003-03-01
影响因子：
27.4
通讯作者：
Kvien, TK
中科院分区：
文献类型：
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作者：
Dadoniene, J;Uhlig, T;Kvien, TK
目的：比较挪威和立陶宛两国类风湿关节炎（RA）患者的疾病特征和健康状况。方法：从维尔纽斯（立陶宛）和奥斯陆（挪威）的RA登记处招募患者。对于维尔纽斯的每一个病人，从奥斯陆的登记册中选择一个年龄和性别相匹配的病人。比较两组患者的社会人口学特征、疾病进程和健康状况。结果：纳入201例立陶宛患者和201例挪威患者。两组患者的平均（SD）年龄为55.9（10.0）岁，其中83%为女性。来自立陶宛的患者较少受雇（27% vs 42%; p = 0.001），疾病活动性评分表达的疾病活动性较高。(DAS28; mean (SD) 5.3 (1.0) v 4.4 (1.4)；p < 0.001)，经改良的健康评估问卷（MHAQ）测定，身体功能较差；均数（SD） 2.3 (0.8) v 1.6 (0.5)；p < 0.001)，有更多的合并症（73% vs 53%; p < 0.001），他们报告的一般健康状况较差，通过简短表格36健康调查(SF-36，平均（SD） 23.2 (13.5) v 44.5 (21.3)；P < 0.001)。使用过疾病缓解药物的患者比例相似，但使用方式不同。结论：两个北欧国家的RA患者在就业、疾病活动、身体功能和自我报告的健康状况方面存在重要差异。可能的解释是社会经济不平等、疾病管理方面的差异和获得专门保健的机会，以及有关工具和数据收集的方法问题。这些数据。支持应根据具体国家需要调整RA管理的观点。
Objective: To compare disease characteristics and health status in patients with rheumatoid arthritis (RA) from two countries, Norway and Lithuania.Methods: Patients were recruited from the RA registers in Vilnius (Lithuania) and Oslo (Norway). For each patient from Vilnius, a patient matched for age and sex from the Oslo register was selected. Sociodemographic characteristics, disease process, and health status were compared between the patient groups.Results: 201 Lithuanian patients and 201 Norwegian patients were included. Mean (SD) age in both groups was 55.9 (10.0) years, and 83% were women. Patients from Lithuania were less often employed (27% v 42%; p = 0.001), had higher disease activity expressed by the disease activity score. (DAS28; mean (SD) 5.3 (1.0) v 4.4 (1.4); p < 0.001), had worse physical function by the modified Health Assessment Questionnaire (MHAQ; mean (SD) 2.3 (0.8) v 1.6 (0.5); p < 0.001), had more often comorbidity (73% v 53%; p < 0.001) and they reported worse general health measured by Short Form-36 Health Survey (SF-36; mean (SD) 23.2 (13.5) v 44.5 (21.3); p < 0.001). The proportions of, patients who had used disease modifying drugs were similar, but the pattern of use differed.Conclusion: Important differences in employment, disease activity, physical function, and self reported health status were observed in patients with RA from two northern European countries. Socioeconomic inequalities, differences in disease management, and access to specialised health care, as well as methodological issues regarding instruments and data collection are likely explanations. These data. support the view that management of RA should be adapted to country-specific needs.