Prostate-specific membrane antigen PET/MRI validation of MR textural analysis for detection of transition zone prostate cancer
Prostate-specific membrane antigen PET/MRI validation of MR textural analysis for detection of transition zone prostate cancer
复制标题
前列腺特异性膜抗原PET/MRI验证MR纹理分析检测移行区前列腺癌
DOI：
10.1007/s00330-017-4877-x
复制
发表时间：
2017-12-01
影响因子：
5.9
通讯作者：
Miles, Kenneth
中科院分区：
文献类型：
--
作者：
Bates, Anthony;Miles, Kenneth
To validate MR textural analysis (MRTA) for detection of transition zone (TZ) prostate cancer through comparison with co-registered prostate-specific membrane antigen (PSMA) PET-MR.Retrospective analysis was performed for 30 men who underwent simultaneous PSMA PET-MR imaging for staging of prostate cancer. Thirty texture features were derived from each manually contoured T2-weighted, transaxial, prostatic TZ using texture analysis software that applies a spatial band-pass filter and quantifies texture through histogram analysis. Texture features of the TZ were compared to PSMA expression on the corresponding PET images. The Benjamini-Hochberg correction controlled the false discovery rate at < 5%.Eighty-eight T2-weighted images in 18 patients demonstrated abnormal PSMA expression within the TZ on PET-MR. 123 images were PSMA negative. Based on the corrected p-value of 0.005, significant differences between PSMA positive and negative slices were found for 16 texture parameters: Standard deviation and mean of positive pixels for all spatial filters (p = < 0.0001 for both at all spatial scaling factor (SSF) values) and mean intensity following filtration for SSF 3-6 mm (p = 0.0002-0.0018).Abnormal expression of PSMA within the TZ is associated with altered texture on T2-weighted MR, providing validation of MRTA for the detection of TZ prostate cancer.
