TEAD family transcription factors in development and disease
TEAD family transcription factors in development and disease
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DOI：
10.1242/dev.196675
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发表时间：
2021-06-01
期刊：
影响因子：
4.6
通讯作者：
Piper, Michael
中科院分区：
文献类型：
--
作者：
Currey, Laura;Thor, Stefan;Piper, Michael
干细胞潜能和谱系特化之间的平衡需要整合外在和内在线索，其最终通过转录因子的活性影响基因表达。其中一个例子是Hippo信号通路，它在发育过程中调节器官大小方面发挥着核心作用。Hippo通路的活性由转录辅因子Yes相关蛋白（雅普）和转录辅激活因子PDZ结合基序（TAZ）介导，它们与TEA结构域（TEAD）蛋白相互作用，调节基因表达。虽然雅普和TAZ的作用已被深入研究，但对TEAD蛋白所起的作用了解较少。最近的研究已经开始解决这个问题，揭示了TEAD在整个发育的各个阶段调节祖细胞自我更新和分化之间的平衡。此外，TEAD蛋白与影响干细胞生物学的其他辅因子相互作用变得越来越明显。本书概述了TEAD蛋白在发育过程中的作用，重点介绍了它们在Hippo信号传导以及其他发育、稳态和疾病背景中的作用。
The balance between stem cell potency and lineage specification entails the integration of both extrinsic and intrinsic cues, which ultimately influence gene expression through the activity of transcription factors. One example of this is provided by the Hippo signalling pathway, which plays a central role in regulating organ size during development. Hippo pathway activity is mediated by the transcriptional co-factors Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ), which interact with TEA domain (TEAD) proteins to regulate gene expression. Although the roles of YAP and TAZ have been intensively studied, the roles played by TEAD proteins are less well understood. Recent studies have begun to address this, revealing that TEADs regulate the balance between progenitor self-renewal and differentiation throughout various stages of development. Furthermore, it is becoming apparent that TEAD proteins interact with other co-factors that influence stem cell biology. This Primer provides an overview of the role of TEAD proteins during development, focusing on their role in Hippo signalling as well as within other developmental, homeostatic and disease contexts.