Association of pathobiologic determinants of atherosclerosis in youth risk score and 15-year change in risk score with carotid artery intima-media thickness in young adults (from The Cardiovascular Risk in Young Finns Study)
Association of pathobiologic determinants of atherosclerosis in youth risk score and 15-year change in risk score with carotid artery intima-media thickness in young adults (from The Cardiovascular Risk in Young Finns Study)
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DOI：
10.1016/j.amjcard.2007.05.035
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发表时间：
2007-10-01
影响因子：
2.8
通讯作者：
Raitakari, Olli T.
中科院分区：
文献类型：
--
作者：
McMahan, C. Alex;Gidding, Samuel S.;Raitakari, Olli T.
青年动脉粥样硬化的病理生物学决定因素（PDAY）研究对15至34岁受试者的尸检结果进行了研究，使用冠心病风险因素（性别、年龄、血清脂蛋白浓度、吸烟、高血压、肥胖和高血糖）制定了风险评分，以估计冠状动脉中晚期动脉粥样硬化病变的概率。芬兰年轻人心血管风险研究在1986年和2001年测量了基于人群的队列中的冠心病风险因素，并在2001年用超声测量了颈动脉内膜中层厚度（IMT）。我们根据1986年12 - 24岁和2001年27 - 39岁的1,279名受试者的危险因素计算了PDAY风险评分。PDAY风险评分早期（即，1986年）和随后15年中风险评分的变化（即，1986年至2001年）是颈动脉内膜中层厚度的独立预测因子; 1986年风险评分中1分的乘数效应为1.008（95%置信区间1.005至1.012），1986年和2001年风险评分之间I点增加的乘法效应为1.003（95%置信区间为1.001至1.006;降低1分的乘法效应为0.997）。总之，在青春期和青年期风险评分随时间的变化（降低或增加），以及生命早期的风险评分，是动脉粥样硬化的重要预测因子。(C)2007年爱思唯尔公司All rights reserved.
The Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study of autopsy findings in subjects 15 to 34 years of age developed a risk score using coronary heart disease risk factors (gender, age, serum lipoprotein concentrations, smoking, hypertension, obesity, and hyperglycemia) to estimate the probability of advanced atherosclerotic lesions in the coronary arteries. The Cardiovascular Risk in Young Finns Study measured coronary heart disease risk factors in a population-based cohort in 1986 and 2001 and measured carotid artery intima-media thickness (IMT) with ultrasonography in 2001. We computed the PDAY risk score from risk factors measured in 1,279 subjects who were 12 to 24 years of age in 1986 and 27 to 39 years of age in 2001. The PDAY risk score early in fife (i.e., 1986) and the change in risk score in the following 15 years (i.e., 1986 through 2001) were independent predictors of carotid artery intima-media thickness; the multiplicative effect of 1 point in the 1986 risk score was 1.008 (95% confidence interval 1.005 to 1.012) and the multiplicative effect of a I-point increase between the 1986 and 2001 risk scores was 1.003 (95% confidence interval 1.001 to 1.006; multiplicative effect of 0.997 for a 1-point decrease). In conclusion, the change in risk score over time (decrease or increase) during adolescence and young adulthood, as well as the risk score early in life, are important predictors of atherosclerosis. (C) 2007 Elsevier Inc. All rights reserved.